Abstract
Overall, more than 50% of marginal zone lymphoma (MZL) patients experience a relapse within 10 years. This phase II trial was conductedto assess the efficacy and safety of oxaliplatin-prednisone (Ox-P) chemotherapy for patients with relapsed or refractory MZL. Patients received oxaliplatin 130 mg/m2 on day 1 and prednisone 100 mg/day on days 1-5 of each cycle. A total of 38 patients were enrolled. The median age of the 34 (16 males, 18 females) evaluated patients was 53 (range = 27-74) years. There were seven complete responses (20.6%) and 15 partial responses (44.1%) (Overall response rate = 64.7%). No treatment-related deaths occurred. The median progression-free survival was 14.2 months (95% CI = 2.1-26.3 months); 3-year overall survival rate was 77.7%. Thus, salvage Ox-P chemotherapy for patients with relapsed or refractory MZL at the stated dosage and schedule showed moderate clinical activity and was considerable in very few selected patients (NCT01068392).
Original language | English (US) |
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Pages (from-to) | 1406-1412 |
Number of pages | 7 |
Journal | Leukemia and Lymphoma |
Volume | 57 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2 2016 |
Bibliographical note
Publisher Copyright:© 2015 Taylor & Francis.
Keywords
- Oxaliplatin
- marginal zone lymphoma
- prednisone
- refractory
- relapse