A phase of liposomes with entangled tubular vesicles

Shivkumar Chiruvolu, Heidi E. Warriner, Edward Naranjo, Stefan H.J. Idziak, Joachim O. Rädler, Robert J. Plano, Joseph A. Zasadzinski, Cyrus R. Safinya

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

An equilibrium phase belonging to the family of bilayer liposomes in ternary mixtures of dimyristoylphosphatidylcholine (DMPC), water, and geraniol (a biological alcohol derived from oil-soluble vitamins that acts as a cosurfactant) has been identified. Electron and optical microscopy reveal the phase, labeled Ltv, to be composed of highly entangled tubular vesicles. In situ x-ray diffraction confirms that the tubule walls are multilamellar with the lipids in the chain-melted state. Macroscopic observations show that the Ltvphase coexists with the well-known L4 phase of spherical vesicles and a bulk Lα phase. However, the defining characteristic of the Ltv phase is the Weissenberg rod climbing effect under shear, which results from its polymer-like entangled microstructure.

Original languageEnglish (US)
Pages (from-to)1222-1225
Number of pages4
JournalScience
Volume266
Issue number5188
DOIs
StatePublished - 1994

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