A phase of liposomes with entangled tubular vesicles

Shivkumar Chiruvolu; Heidi E. Warriner; Edward Naranjo; Stefan H.J. Idziak; Joachim O. Rädler; Robert J. Plano; Joseph A. Zasadzinski; Cyrus R. Safinya

doi:10.1126/science.7973704

A phase of liposomes with entangled tubular vesicles

Shivkumar Chiruvolu, Heidi E. Warriner, Edward Naranjo, Stefan H.J. Idziak, Joachim O. Rädler, Robert J. Plano, Joseph A. Zasadzinski, Cyrus R. Safinya

Chemical Engineering and Materials Science

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Abstract

An equilibrium phase belonging to the family of bilayer liposomes in ternary mixtures of dimyristoylphosphatidylcholine (DMPC), water, and geraniol (a biological alcohol derived from oil-soluble vitamins that acts as a cosurfactant) has been identified. Electron and optical microscopy reveal the phase, labeled L_tv, to be composed of highly entangled tubular vesicles. In situ x-ray diffraction confirms that the tubule walls are multilamellar with the lipids in the chain-melted state. Macroscopic observations show that the L_tvphase coexists with the well-known L₄ phase of spherical vesicles and a bulk Lα phase. However, the defining characteristic of the L_tv phase is the Weissenberg rod climbing effect under shear, which results from its polymer-like entangled microstructure.

Original language	English (US)
Pages (from-to)	1222-1225
Number of pages	4
Journal	Science
Volume	266
Issue number	5188
DOIs	https://doi.org/10.1126/science.7973704
State	Published - 1994

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title = "A phase of liposomes with entangled tubular vesicles",

abstract = "An equilibrium phase belonging to the family of bilayer liposomes in ternary mixtures of dimyristoylphosphatidylcholine (DMPC), water, and geraniol (a biological alcohol derived from oil-soluble vitamins that acts as a cosurfactant) has been identified. Electron and optical microscopy reveal the phase, labeled Ltv, to be composed of highly entangled tubular vesicles. In situ x-ray diffraction confirms that the tubule walls are multilamellar with the lipids in the chain-melted state. Macroscopic observations show that the Ltvphase coexists with the well-known L4 phase of spherical vesicles and a bulk Lα phase. However, the defining characteristic of the Ltv phase is the Weissenberg rod climbing effect under shear, which results from its polymer-like entangled microstructure.",

author = "Shivkumar Chiruvolu and Warriner, {Heidi E.} and Edward Naranjo and Idziak, {Stefan H.J.} and R{\"a}dler, {Joachim O.} and Plano, {Robert J.} and Zasadzinski, {Joseph A.} and Safinya, {Cyrus R.}",

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AU - Chiruvolu, Shivkumar

AU - Warriner, Heidi E.

AU - Naranjo, Edward

AU - Idziak, Stefan H.J.

AU - Rädler, Joachim O.

AU - Plano, Robert J.

AU - Zasadzinski, Joseph A.

AU - Safinya, Cyrus R.

PY - 1994

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AB - An equilibrium phase belonging to the family of bilayer liposomes in ternary mixtures of dimyristoylphosphatidylcholine (DMPC), water, and geraniol (a biological alcohol derived from oil-soluble vitamins that acts as a cosurfactant) has been identified. Electron and optical microscopy reveal the phase, labeled Ltv, to be composed of highly entangled tubular vesicles. In situ x-ray diffraction confirms that the tubule walls are multilamellar with the lipids in the chain-melted state. Macroscopic observations show that the Ltvphase coexists with the well-known L4 phase of spherical vesicles and a bulk Lα phase. However, the defining characteristic of the Ltv phase is the Weissenberg rod climbing effect under shear, which results from its polymer-like entangled microstructure.

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A phase of liposomes with entangled tubular vesicles

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