A pilot study of combination therapy with indinavir, stavudine (d4T), and didanosine (ddI) in children infected with the human immunodeficiency virus

M. W. Kline; C. V. Fletcher; A. T. Harris; K. D. Evans; R. C. Brundage; R. P. Remmel; N. R. Calles; S. B. Kirkpatrick; C. Simon

doi:10.1016/S0022-3476(98)70039-3

A pilot study of combination therapy with indinavir, stavudine (d4T), and didanosine (ddI) in children infected with the human immunodeficiency virus

M. W. Kline, C. V. Fletcher, A. T. Harris, K. D. Evans, R. C. Brundage, R. P. Remmel, N. R. Calles, S. B. Kirkpatrick, C. Simon

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Abstract

Twelve children infected with the human immunodeficiency virus were treated orally with indinavir, stavudine, plus didanosine for 12 to 48 weeks. Therapy was limited in some cases by nonadherence, intolerance, toxicity, and virologic failure. Marked increases in CD4+ lymphocyte counts and decreases in plasma human immunodeficiency virus RNA concentrations suggest that the regimen has potent antiviral activity.

Original language	English (US)
Pages (from-to)	543-546
Number of pages	4
Journal	Journal of Pediatrics
Volume	132
Issue number	3 I
DOIs	https://doi.org/10.1016/S0022-3476(98)70039-3
State	Published - 1998

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Kline, M. W., Fletcher, C. V., Harris, A. T., Evans, K. D., Brundage, R. C., Remmel, R. P., Calles, N. R., Kirkpatrick, S. B., & Simon, C. (1998). A pilot study of combination therapy with indinavir, stavudine (d4T), and didanosine (ddI) in children infected with the human immunodeficiency virus. Journal of Pediatrics, 132(3 I), 543-546. https://doi.org/10.1016/S0022-3476(98)70039-3

Kline, MW, Fletcher, CV, Harris, AT, Evans, KD, Brundage, RC, Remmel, RP, Calles, NR, Kirkpatrick, SB & Simon, C 1998, 'A pilot study of combination therapy with indinavir, stavudine (d4T), and didanosine (ddI) in children infected with the human immunodeficiency virus', Journal of Pediatrics, vol. 132, no. 3 I, pp. 543-546. https://doi.org/10.1016/S0022-3476(98)70039-3

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AU - Harris, A. T.

AU - Evans, K. D.

AU - Brundage, R. C.

AU - Remmel, R. P.

AU - Calles, N. R.

AU - Kirkpatrick, S. B.

AU - Simon, C.

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A pilot study of combination therapy with indinavir, stavudine (d4T), and didanosine (ddI) in children infected with the human immunodeficiency virus

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