TY - JOUR
T1 - A plant vacuolar protease, VPE, mediates, virus-induced hypersensitive cell death
AU - Hatsugai, Noriyuki
AU - Kuroyanagi, Miwa
AU - Yamada, Kenji
AU - Meshi, Tetsuo
AU - Tsuda, Shinya
AU - Kondo, Maki
AU - Nishimura, Mikio
AU - Hara-Nishimura, Ikuko
PY - 2004/8/6
Y1 - 2004/8/6
N2 - Programmed cell death (PCD) in animals depends on caspase protease activity. Plants also exhibit PCD, for example as a response to pathogens, although a plant caspase remains elusive. Here we show that vacuolar processing enzyme (VPE) is a protease essential for a virus-induced hypersensitive response that involves PCD. VPE deficiency prevented virus-induced hypersensitive cell death in tobacco plants. VPE is structurally unrelated to caspases, although VPE has a caspase-1 activity. Thus, plants have evolved a regulated cellular suicide strategy that, unlike PCD of animals, is mediated by VPE and the cellular vacuole.
AB - Programmed cell death (PCD) in animals depends on caspase protease activity. Plants also exhibit PCD, for example as a response to pathogens, although a plant caspase remains elusive. Here we show that vacuolar processing enzyme (VPE) is a protease essential for a virus-induced hypersensitive response that involves PCD. VPE deficiency prevented virus-induced hypersensitive cell death in tobacco plants. VPE is structurally unrelated to caspases, although VPE has a caspase-1 activity. Thus, plants have evolved a regulated cellular suicide strategy that, unlike PCD of animals, is mediated by VPE and the cellular vacuole.
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UR - http://www.scopus.com/inward/citedby.url?scp=3843128438&partnerID=8YFLogxK
U2 - 10.1126/science.1099859
DO - 10.1126/science.1099859
M3 - Article
C2 - 15297671
AN - SCOPUS:3843128438
SN - 0036-8075
VL - 305
SP - 855
EP - 858
JO - Science
JF - Science
IS - 5685
ER -
