A plant vacuolar protease, VPE, mediates, virus-induced hypersensitive cell death

Noriyuki Hatsugai, Miwa Kuroyanagi, Kenji Yamada, Tetsuo Meshi, Shinya Tsuda, Maki Kondo, Mikio Nishimura, Ikuko Hara-Nishimura

Research output: Contribution to journalArticlepeer-review

452 Scopus citations

Abstract

Programmed cell death (PCD) in animals depends on caspase protease activity. Plants also exhibit PCD, for example as a response to pathogens, although a plant caspase remains elusive. Here we show that vacuolar processing enzyme (VPE) is a protease essential for a virus-induced hypersensitive response that involves PCD. VPE deficiency prevented virus-induced hypersensitive cell death in tobacco plants. VPE is structurally unrelated to caspases, although VPE has a caspase-1 activity. Thus, plants have evolved a regulated cellular suicide strategy that, unlike PCD of animals, is mediated by VPE and the cellular vacuole.

Original languageEnglish (US)
Pages (from-to)855-858
Number of pages4
JournalScience
Volume305
Issue number5685
DOIs
StatePublished - Aug 6 2004

Fingerprint Dive into the research topics of 'A plant vacuolar protease, VPE, mediates, virus-induced hypersensitive cell death'. Together they form a unique fingerprint.

Cite this