A positive-negative mode of population covariation links brain connectivity, demographics and behavior

Stephen M. Smith; Thomas E. Nichols; Diego Vidaurre; Anderson M. Winkler; Timothy E J Behrens; Matthew F. Glasser; Kamil Ugurbil; Deanna M. Barch; David C. Van Essen; Karla L. Miller

doi:10.1038/nn.4125

A positive-negative mode of population covariation links brain connectivity, demographics and behavior

Stephen M. Smith, Thomas E. Nichols, Diego Vidaurre, Anderson M. Winkler, Timothy E J Behrens, Matthew F. Glasser, Kamil Ugurbil, Deanna M. Barch, David C. Van Essen, Karla L. Miller

Radiology

Research output: Contribution to journal › Short survey › peer-review

526 Scopus citations

Abstract

We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.

Original language	English (US)
Pages (from-to)	1565-1567
Number of pages	3
Journal	Nature neuroscience
Volume	18
Issue number	11
DOIs	https://doi.org/10.1038/nn.4125
State	Published - Nov 1 2015

Bibliographical note

Funding Information:
We thank our many colleagues in the WU-Minn HCP Consortium for their invaluable contributions in generating the publicly available HCP data and implementing the procedures needed to acquire, analyze, visualize and share these data sets. We are grateful for funding from the US National Institutes of Health (grants 1U54MH091657, P30-NS057091, P41-RR08079/EB015894 and F30-MH097312) and the Wellcome Trust (grants 098369/Z/12/Z and 091509/Z/10/Z).

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© 2015 Nature America, Inc.

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AU - Glasser, Matthew F.

AU - Ugurbil, Kamil

AU - Barch, Deanna M.

AU - Van Essen, David C.

AU - Miller, Karla L.

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A positive-negative mode of population covariation links brain connectivity, demographics and behavior

Abstract

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