A programmable fully-integrated microstimulator for neural implants and instrumentation

Anh Tuan Nguyen, Jian Xu, Wing Kin Tam, Wenfeng Zhao, Tong Wu, Zhi Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

This paper presents a fully-integrated stimulator chip for electrical microstimulation. The device is designed in a high-voltage process that allows up to 20V power supply and 19V output voltage compliance. A broad range of current-mode stimulation waveforms and patterns can be generated, including symmetrical/asymmetrical, biphasic/monophasic, and pulse train stimuli. The current amplitude, pulse width, and stimulation rate are adjustable from 0.5μA to 2mA, 100μs to 4ms, and 0.1Hz to 200Hz, respectively. Two complementary charge-balancing techniques are integrated to reduce residual voltage and stimulation artifacts. In in vitro experiments, the stimulator is demonstrated to trigger neural spikes, modulate neuronal firing rate, and alter mesoscopic neuronal activity. The results suggest the proposed microstimulator can support a wide variety of neuroscience experiments that require electrical microstimulation.

Original languageEnglish (US)
Title of host publicationProceedings - 2016 IEEE Biomedical Circuits and Systems Conference, BioCAS 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages472-475
Number of pages4
ISBN (Electronic)9781509029594
DOIs
StatePublished - Jan 1 2016
Event12th IEEE Biomedical Circuits and Systems Conference, BioCAS 2016 - Shanghai, China
Duration: Oct 17 2016Oct 19 2016

Publication series

NameProceedings - 2016 IEEE Biomedical Circuits and Systems Conference, BioCAS 2016

Other

Other12th IEEE Biomedical Circuits and Systems Conference, BioCAS 2016
CountryChina
CityShanghai
Period10/17/1610/19/16

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