A proposed mechanism of ALS fails the test in vivo

Harry T. Orr

doi:10.1038/nn0402-287

A proposed mechanism of ALS fails the test in vivo

Harry T. Orr

Laboratory Medicine and Pathology

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

In contrast to prevailing hypotheses, a genetic study shows that the toxic gain of function associated with mutant superoxide dismutase in familial amyotropic lateral sclerosis is unlikely to be due to changes in its oxidative activity causing an increase in free radicals.

Original language	English (US)
Pages (from-to)	287-288
Number of pages	2
Journal	Nature neuroscience
Volume	5
Issue number	4
DOIs	https://doi.org/10.1038/nn0402-287
State	Published - 2002

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title = "A proposed mechanism of ALS fails the test in vivo",

abstract = "In contrast to prevailing hypotheses, a genetic study shows that the toxic gain of function associated with mutant superoxide dismutase in familial amyotropic lateral sclerosis is unlikely to be due to changes in its oxidative activity causing an increase in free radicals.",

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A proposed mechanism of ALS fails the test in vivo

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