A prospective study of neuropsychiatric symptoms associated with interferon-α-2b and ribavirin therapy for patients with chronic hepatitis C

Eric Dieperink, Samuel B. Ho, Paul Thuras, Mark L. Willenbring

Research output: Contribution to journalArticlepeer-review

202 Scopus citations

Abstract

The purpose of this study was to systematically describe the neuropsychiatric side effects of treatment with interferon-α-2b (INF-α) and ribavirin in patients with chronic hepatitis C as well as to compare different instruments used to measure these side effects. Fifty-five patients with chronic hepatitis C were prospectively followed for 24 weeks and assessed with seven neuropsychiatric symptom measures and one quality of life scale. Of 42 patients treated with INF-α and ribavirin, 11 (26%) were receiving psychiatric treatment at baseline. They scored higher on all rating scales at baseline and became more symptomatic during treatment. Of the 31 patients (74%) not in psychiatric care at baseline, 15 (48%) required treatment for neuropsychiatric symptoms, and seven (23%) met criteria for major depression during INF-α therapy. The control group of 13 untreated subjects showed little change over the 24-week period. All symptom scales were highly intercorrelated, suggesting that use of one is sufficient for monitoring symptoms.

Original languageEnglish (US)
Pages (from-to)104-112
Number of pages9
JournalPsychosomatics
Volume44
Issue number2
DOIs
StatePublished - 2003
Externally publishedYes

Bibliographical note

Funding Information:
Supported by the Minneapolis VA Hepatitis C Resource Center , the Research Service of the Department of Veterans Affairs , and an unrestricted grant from Schering-Plough .

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Fingerprint Dive into the research topics of 'A prospective study of neuropsychiatric symptoms associated with interferon-α-2b and ribavirin therapy for patients with chronic hepatitis C'. Together they form a unique fingerprint.

Cite this