A prospective study of the predictive value of polymerase chain reaction assay for cytomegalovirus in asymptomatic kidney transplant recipients

Enrico Benedetti, Michael Mihalov, Massimo Asolati, John Kirby, Ty Dunn, Vandad Raofi, Magali Fontaine, Raymond Pollak

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Cytomegalovirus (CMV) infection carries the potential for high morbidity in transplant recipients. The institution of pre-emptive therapy prior to the onset of clinical disease on the basis of CMV-polymerase chain reaction (PCR) is very attractive. We prospectively studied 52 asymptomatic kidney transplant recipients to test the hypothesis that serial CMV-PCR assays during the first 3 months post-transplant would identify patients at risk for CMV disease. Twenty-three patients (44.2%) had positive CMV-PCR tests at least once; 2 (8.6%) developed CMV. None of the 29 patients continuously negative for CMV-PCR developed CMV disease. CMV-PCR status did not influence patient and graft survival or the incidence of acute rejection. We conclude that while a substantial number of kidney transplant recipients become positive for CMV-PCR in the early post-transplant period, only a minority will develop CMV disease. Negative CMV-PCR assay is an accurate negative predictor for CMV disease but the value of CMV-PCR as a guide for pre-emptive anti-CMV therapy in kidney transplant recipients appears limited.

Original languageEnglish (US)
Pages (from-to)391-395
Number of pages5
JournalClinical Transplantation
Volume12
Issue number5
StatePublished - Oct 1 1998

Keywords

  • Cytomegalovirus
  • Kidney transplant
  • Polymerase chain reaction
  • Pre-emptive therapy

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