TY - JOUR
T1 - A rare case of recurrent pituitary collision tumors
AU - Shakally, Almoutaz
AU - Tahara, Naoyuki
AU - Clark, Brent
AU - Tummala, Ramachandra
AU - Caicedo-Granados, Emiro
AU - Kawakami, Yasuhiko
AU - Araki, Takako
N1 - Publisher Copyright:
© Endocrine Society 2020.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Pituitary collision tumors are sporadically reported and rare. We present a case of pituitary collision tumors with nonfunctioning pituitary adenoma (NFPA) and craniopharyngioma. In order to look for any common activated pathway, we examined WNT/β-CATENIN signaling activation, known to be involved in tumorigenesis in both craniopharyngioma and NFPA. We found nuclear accumulation of β-CATENIN protein and expression of LEF1 protein, markers of active β-CATENIN signaling in the craniopharyngioma but not in the pituitary adenomas. In our case, the NFPA is invasive macroadenoma, which is a frequently identified type of pituitary adenoma in collision tumor cases. Recurrence of this tumor was first observed after 8 years of follow-up. Based on this case, we suggest that pituitary collision tumors require long-term follow-up.
AB - Pituitary collision tumors are sporadically reported and rare. We present a case of pituitary collision tumors with nonfunctioning pituitary adenoma (NFPA) and craniopharyngioma. In order to look for any common activated pathway, we examined WNT/β-CATENIN signaling activation, known to be involved in tumorigenesis in both craniopharyngioma and NFPA. We found nuclear accumulation of β-CATENIN protein and expression of LEF1 protein, markers of active β-CATENIN signaling in the craniopharyngioma but not in the pituitary adenomas. In our case, the NFPA is invasive macroadenoma, which is a frequently identified type of pituitary adenoma in collision tumor cases. Recurrence of this tumor was first observed after 8 years of follow-up. Based on this case, we suggest that pituitary collision tumors require long-term follow-up.
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U2 - 10.1210/jendso/bvaa089
DO - 10.1210/jendso/bvaa089
M3 - Article
C2 - 32783016
AN - SCOPUS:85096460681
SN - 2472-1972
VL - 4
JO - Journal of the Endocrine Society
JF - Journal of the Endocrine Society
IS - 9
ER -