TY - JOUR
T1 - A reinvigorated era of bacterial secondary metabolite discovery
AU - Sidebottom, Ashley M.
AU - Carlson, Erin E.
N1 - Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Secondary metabolite discovery from bacteria has become increasingly successful in the last decade due to the advancement of integrated genetic-based, spectrometric-based and informatics-based techniques. Microbes and their unique metabolic outputs have been widely studied since the beginning of modern medicine however, it is well known that the current repertoire of secondary metabolites, or more commonly natural products, is incomplete and the understanding of natural product-mediated intracellular dialog is in its infancy. Here, we highlight the present state of bacterial metabolomics including compound discovery approaches and new strategies for probing the role of these molecules within communication networks.
AB - Secondary metabolite discovery from bacteria has become increasingly successful in the last decade due to the advancement of integrated genetic-based, spectrometric-based and informatics-based techniques. Microbes and their unique metabolic outputs have been widely studied since the beginning of modern medicine however, it is well known that the current repertoire of secondary metabolites, or more commonly natural products, is incomplete and the understanding of natural product-mediated intracellular dialog is in its infancy. Here, we highlight the present state of bacterial metabolomics including compound discovery approaches and new strategies for probing the role of these molecules within communication networks.
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U2 - 10.1016/j.cbpa.2014.10.014
DO - 10.1016/j.cbpa.2014.10.014
M3 - Review article
C2 - 25461728
AN - SCOPUS:84913555115
SN - 1367-5931
VL - 24
SP - 104
EP - 111
JO - Current opinion in chemical biology
JF - Current opinion in chemical biology
ER -