TY - JOUR
T1 - A Retrospective Analysis of Antithrombin III Replacement Therapy for the Treatment of Hepatic Sinusoidal Obstruction Syndrome in Children Following Hematopoietic Stem Cell Transplantation
AU - Kim, Miriam
AU - Rao, Seema
AU - Eickhoff, Jens C.
AU - Desantes, Kenneth B.
AU - Capitini, Christian M.
N1 - Publisher Copyright:
© 2019 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Hepatic sinusoidal obstruction syndrome (SOS) remains a serious complication of hematopoietic stem cell transplantation (HSCT). In this single institution retrospective case series, 18 children developed SOS after HSCT. Patients were treated with antithrombin III (ATIII), defibrotide, or ATIII followed by defibrotide. Twelve of 13 patients who were treated with ATIII therapy alone had complete resolution of SOS, including 4 of 5 children with severe SOS. In this limited cohort, ATIII was safe and successfully prevented progression of hepatic SOS following HSCT in the majority of children at our center.
AB - Hepatic sinusoidal obstruction syndrome (SOS) remains a serious complication of hematopoietic stem cell transplantation (HSCT). In this single institution retrospective case series, 18 children developed SOS after HSCT. Patients were treated with antithrombin III (ATIII), defibrotide, or ATIII followed by defibrotide. Twelve of 13 patients who were treated with ATIII therapy alone had complete resolution of SOS, including 4 of 5 children with severe SOS. In this limited cohort, ATIII was safe and successfully prevented progression of hepatic SOS following HSCT in the majority of children at our center.
KW - BMT
KW - antithrombin III
KW - sinusoidal obstruction syndrome
KW - stem cell transplantation
KW - venoocclusive disease
UR - http://www.scopus.com/inward/record.url?scp=85060376328&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060376328&partnerID=8YFLogxK
U2 - 10.1097/MPH.0000000000001422
DO - 10.1097/MPH.0000000000001422
M3 - Article
C2 - 30676436
AN - SCOPUS:85060376328
SN - 1077-4114
VL - 42
SP - 145
EP - 148
JO - Journal of pediatric hematology/oncology
JF - Journal of pediatric hematology/oncology
IS - 2
ER -