A review of genetics, arterial stiffness, and blood pressure in african americans

Jennifer L. Hall, Daniel A. Duprez, Ana Barac, Stephen S. Rich

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The prevalence of hypertension in African Americans in the USA is among the highest in the world and increasing. The identification of genes and pathways regulating blood pressure in African Americans has been challenging. An early predictor of hypertension is arterial stiffness. The prevalence of arterial stiffness is significantly higher in African Americans compared to Caucasians. Approximately 20 % of the variance in arterial stiffness is estimated to be heritable. Identifying genes and biological pathways regulating arterial stiffness may provide insight into the genetics underlying the increased risk of hypertension in African Americans. This paper reviews the genetic findings to date in the area of arterial stiffness and blood pressure in African Americans with an emphasis on the current limitations and new efforts to move the field forward.

Original languageEnglish (US)
Pages (from-to)302-308
Number of pages7
JournalJournal of cardiovascular translational research
Volume5
Issue number3
DOIs
StatePublished - Jun 2012

Keywords

  • African Americans
  • Arterial elasticity
  • Arterial stiffness
  • Collagen
  • Compliance
  • DNA
  • Elastin
  • Genetics
  • Health and medicine
  • SNP
  • Variants

Fingerprint Dive into the research topics of 'A review of genetics, arterial stiffness, and blood pressure in african americans'. Together they form a unique fingerprint.

Cite this