A review of GHRH stimulation test in psychiatry

Stacy S. Skare, Maurice W. Dysken, Charles J. Billington

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

We critically reviewed controlled investigations of the growth hormone relaasing hormone (GHRH) stimulation test in depression, anorexia nervosa, bulimia, panic disorder, schizophrenia, and Alzheimer's disease. Comparisons of GH responsiveness between patients and controls within each diagnostic category were equivocal and in some cases contradictory. Factors that may contribute substantially to the inconsistent findings within diagnostic categories include (1) the variability of GHRH-simulated GH among control groups; (2) the lack of uniformity in test procedures and outcome measures; and (3) the age and gender of subjects. In addition, the individual reproducibility of the GHRH stimulation test has not been adequately investigated and until the test's stability within subjects can be determined, the validity of interpretations resulting from the GHRH simulation test are in question.

Original languageEnglish (US)
Pages (from-to)249-265
Number of pages17
JournalBiological Psychiatry
Volume36
Issue number4
DOIs
StatePublished - Aug 15 1994

Keywords

  • Alzheimer's disease
  • Growth hormone releasing hormone (GHRH), growth hormone (GH), depression, eating disorder, panic disorder
  • schizophrenia

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