TY - JOUR
T1 - A Review on Platelet Activating Factor Inhibitors
T2 - Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?
AU - Papakonstantinou, Vasiliki D.
AU - Lagopati, Nefeli
AU - Tsilibary, Effie C.
AU - Demopoulos, Constantinos A.
AU - Philippopoulos, Athanassios I.
N1 - Publisher Copyright:
© 2017 Vasiliki D. Papakonstantinou et al.
PY - 2017
Y1 - 2017
N2 - In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new class of the so-called metal-based inhibitors of PAF. A small library of 30 metal complexes has been thus created; their anti-inflammatory activity has been further evaluated owing to their inhibitory effect against PAF in washed rabbit platelets (WRPs). In addition, emphasis has also been placed on the identification of preliminary structure-activity relationships for the different classes of metal-based inhibitors.
AB - In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new class of the so-called metal-based inhibitors of PAF. A small library of 30 metal complexes has been thus created; their anti-inflammatory activity has been further evaluated owing to their inhibitory effect against PAF in washed rabbit platelets (WRPs). In addition, emphasis has also been placed on the identification of preliminary structure-activity relationships for the different classes of metal-based inhibitors.
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U2 - 10.1155/2017/6947034
DO - 10.1155/2017/6947034
M3 - Review article
C2 - 28458618
AN - SCOPUS:85018645341
SN - 1565-3633
VL - 2017
JO - Bioinorganic Chemistry and Applications
JF - Bioinorganic Chemistry and Applications
M1 - 6947034
ER -
