A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?

Vasiliki D. Papakonstantinou, Nefeli Lagopati, Effie C. Tsilibary, Constantinos A. Demopoulos, Athanassios I. Philippopoulos

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new class of the so-called metal-based inhibitors of PAF. A small library of 30 metal complexes has been thus created; their anti-inflammatory activity has been further evaluated owing to their inhibitory effect against PAF in washed rabbit platelets (WRPs). In addition, emphasis has also been placed on the identification of preliminary structure-activity relationships for the different classes of metal-based inhibitors.

Original languageEnglish (US)
Article number6947034
JournalBioinorganic Chemistry and Applications
Volume2017
DOIs
StatePublished - 2017

Bibliographical note

Publisher Copyright:
© 2017 Vasiliki D. Papakonstantinou et al.

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