A salience misattribution model for addictive-like behaviors

Shivam Kalhan, A. David Redish, Robert Hester, Marta I. Garrido

Research output: Contribution to journalReview articlepeer-review

Abstract

Adapting to the changing environment is a key component of optimal decision-making. Internal-models that accurately represent and selectively update from behaviorally relevant/salient stimuli may facilitate adaptive behaviors. Anterior cingulate cortex (ACC) and dopaminergic systems may produce these adaptive internal-models through selective updates from behaviorally relevant stimuli. Dysfunction of ACC and dopaminergic systems could therefore produce misaligned internal-models where updates are disproportionate to the salience of the cues. An aspect of addictive-like behaviors is reduced adaptation and, ACC and dopaminergic systems typically exhibit dysfunction in drug-dependents. We argue that ACC and dopaminergic dysfunction in dependents may produce misaligned internal-models such that drug-related stimuli are misattributed with a higher salience compared to non-drug related stimuli. Hence, drug-related rewarding stimuli generate over-weighted updates to the internal-model, while negative feedback and non-drug related rewarding stimuli generate down-weighted updates. This misaligned internal-model may therefore incorrectly reinforce maladaptive drug-related behaviors. We use the proposed framework to discuss ways behavior may be made more adaptive and how the framework may be supported or falsified experimentally.

Original languageEnglish (US)
Pages (from-to)466-477
Number of pages12
JournalNeuroscience and Biobehavioral Reviews
Volume125
DOIs
StatePublished - Jun 2021

Bibliographical note

Funding Information:
Shivam Kalhan was supported by the Velma Stanley PhD Scholarship and by the Australian Government Research Training Program Scholarship , provided by the Australian Commonwealth Government and the University of Melbourne .

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

  • Adaptation
  • Addiction
  • Anterior cingulate cortex
  • Decision-making
  • Dopamine
  • Internal-model updating
  • Prediction-errors
  • Salience

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't

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