A simulation study of the combined thermoelectric extracellular stimulation of the sciatic nerve of the xenopus laevis: The localized transient heat block

Zongxia Mou; Iasonas F. Triantis; Virginia M. Woods; Christofer Toumazou; Konstantin Nikolic

doi:10.1109/TBME.2012.2194146

A simulation study of the combined thermoelectric extracellular stimulation of the sciatic nerve of the xenopus laevis: The localized transient heat block

Zongxia Mou, Iasonas F. Triantis, Virginia M. Woods, Christofer Toumazou, Konstantin Nikolic

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The electrical behavior of the Xenopus laevis nerve fibers was studied when combined electrical (cuff electrodes) and optical (infrared laser, low power sub-5mW) stimulations are applied. Assuming that the main effect of the laser irradiation on the nerve tissue is the localized temperature increase, this paper analyzes and gives new insights into the function of the combined thermoelectric stimulation on both excitation and blocking of the nerve action potentials (AP). The calculations involve a finite-element model (COMSOL) to represent the electrical properties of the nerve and cuff. Electric-field distribution along the nerve was computed for the given stimulation current profile and imported into a NEURON model, which was built to simulate the electrical behavior of myelinated nerve fiber under extracellular stimulation. The main result of this study of combined thermoelectric stimulation showed that local temperature increase, for the given electric field, can create a transient block of both the generation and propagation of the APs. Some preliminary experimental data in support of this conclusion are also shown.

Original language	English (US)
Article number	2194146
Pages (from-to)	1758-1769
Number of pages	12
Journal	IEEE Transactions on Biomedical Engineering
Volume	59
Issue number	6
DOIs	https://doi.org/10.1109/TBME.2012.2194146
State	Published - 2012
Externally published	Yes

Bibliographical note

Funding Information:
Manuscript received October 24, 2011; revised February 27, 2012; accepted March 20, 2012. Date of publication April 9, 2012; date of current version May 18, 2012. This work was supported in part by the U.K. Engineering and Physical Sciences Research Council under Grant EP/H024581. The work of Z. Mou was supported by the China Scholarship Council. The work of K. Nikolic was supported in part by the EU SeeBetter Project 270324. Asterisk indicates corresponding author.

Keywords

Extracellular stimulation
NEURON
finite-element method
heat block
neural engineering

Access

10.1109/TBME.2012.2194146

OpenUrl availability

Full text

Cite this

A simulation study of the combined thermoelectric extracellular stimulation of the sciatic nerve of the xenopus laevis: The localized transient heat block. / Mou, Zongxia; Triantis, Iasonas F.; Woods, Virginia M. et al.
In: IEEE Transactions on Biomedical Engineering, Vol. 59, No. 6, 2194146, 2012, p. 1758-1769.

Research output: Contribution to journal › Article › peer-review

@article{c1669448a83e41c1a1db57f78da69ff3,

title = "A simulation study of the combined thermoelectric extracellular stimulation of the sciatic nerve of the xenopus laevis: The localized transient heat block",

abstract = "The electrical behavior of the Xenopus laevis nerve fibers was studied when combined electrical (cuff electrodes) and optical (infrared laser, low power sub-5mW) stimulations are applied. Assuming that the main effect of the laser irradiation on the nerve tissue is the localized temperature increase, this paper analyzes and gives new insights into the function of the combined thermoelectric stimulation on both excitation and blocking of the nerve action potentials (AP). The calculations involve a finite-element model (COMSOL) to represent the electrical properties of the nerve and cuff. Electric-field distribution along the nerve was computed for the given stimulation current profile and imported into a NEURON model, which was built to simulate the electrical behavior of myelinated nerve fiber under extracellular stimulation. The main result of this study of combined thermoelectric stimulation showed that local temperature increase, for the given electric field, can create a transient block of both the generation and propagation of the APs. Some preliminary experimental data in support of this conclusion are also shown.",

keywords = "Extracellular stimulation, NEURON, finite-element method, heat block, neural engineering",

author = "Zongxia Mou and Triantis, {Iasonas F.} and Woods, {Virginia M.} and Christofer Toumazou and Konstantin Nikolic",

note = "Funding Information: Manuscript received October 24, 2011; revised February 27, 2012; accepted March 20, 2012. Date of publication April 9, 2012; date of current version May 18, 2012. This work was supported in part by the U.K. Engineering and Physical Sciences Research Council under Grant EP/H024581. The work of Z. Mou was supported by the China Scholarship Council. The work of K. Nikolic was supported in part by the EU SeeBetter Project 270324. Asterisk indicates corresponding author.",

year = "2012",

doi = "10.1109/TBME.2012.2194146",

language = "English (US)",

volume = "59",

pages = "1758--1769",

journal = "IEEE Transactions on Biomedical Engineering",

issn = "0018-9294",

publisher = "IEEE Computer Society",

number = "6",

}

TY - JOUR

T1 - A simulation study of the combined thermoelectric extracellular stimulation of the sciatic nerve of the xenopus laevis

T2 - The localized transient heat block

AU - Mou, Zongxia

AU - Triantis, Iasonas F.

AU - Woods, Virginia M.

AU - Toumazou, Christofer

AU - Nikolic, Konstantin

N1 - Funding Information: Manuscript received October 24, 2011; revised February 27, 2012; accepted March 20, 2012. Date of publication April 9, 2012; date of current version May 18, 2012. This work was supported in part by the U.K. Engineering and Physical Sciences Research Council under Grant EP/H024581. The work of Z. Mou was supported by the China Scholarship Council. The work of K. Nikolic was supported in part by the EU SeeBetter Project 270324. Asterisk indicates corresponding author.

PY - 2012

Y1 - 2012

N2 - The electrical behavior of the Xenopus laevis nerve fibers was studied when combined electrical (cuff electrodes) and optical (infrared laser, low power sub-5mW) stimulations are applied. Assuming that the main effect of the laser irradiation on the nerve tissue is the localized temperature increase, this paper analyzes and gives new insights into the function of the combined thermoelectric stimulation on both excitation and blocking of the nerve action potentials (AP). The calculations involve a finite-element model (COMSOL) to represent the electrical properties of the nerve and cuff. Electric-field distribution along the nerve was computed for the given stimulation current profile and imported into a NEURON model, which was built to simulate the electrical behavior of myelinated nerve fiber under extracellular stimulation. The main result of this study of combined thermoelectric stimulation showed that local temperature increase, for the given electric field, can create a transient block of both the generation and propagation of the APs. Some preliminary experimental data in support of this conclusion are also shown.

AB - The electrical behavior of the Xenopus laevis nerve fibers was studied when combined electrical (cuff electrodes) and optical (infrared laser, low power sub-5mW) stimulations are applied. Assuming that the main effect of the laser irradiation on the nerve tissue is the localized temperature increase, this paper analyzes and gives new insights into the function of the combined thermoelectric stimulation on both excitation and blocking of the nerve action potentials (AP). The calculations involve a finite-element model (COMSOL) to represent the electrical properties of the nerve and cuff. Electric-field distribution along the nerve was computed for the given stimulation current profile and imported into a NEURON model, which was built to simulate the electrical behavior of myelinated nerve fiber under extracellular stimulation. The main result of this study of combined thermoelectric stimulation showed that local temperature increase, for the given electric field, can create a transient block of both the generation and propagation of the APs. Some preliminary experimental data in support of this conclusion are also shown.

KW - Extracellular stimulation

KW - NEURON

KW - finite-element method

KW - heat block

KW - neural engineering

UR - http://www.scopus.com/inward/record.url?scp=84861379607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861379607&partnerID=8YFLogxK

U2 - 10.1109/TBME.2012.2194146

DO - 10.1109/TBME.2012.2194146

M3 - Article

C2 - 22510941

AN - SCOPUS:84861379607

SN - 0018-9294

VL - 59

SP - 1758

EP - 1769

JO - IEEE Transactions on Biomedical Engineering

JF - IEEE Transactions on Biomedical Engineering

IS - 6

M1 - 2194146

ER -

A simulation study of the combined thermoelectric extracellular stimulation of the sciatic nerve of the xenopus laevis: The localized transient heat block

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this