A single immunization with a recombinant canine adenovirus type 2 expressing the seoul virus Gn glycoprotein confers protective immunity against seoul virus in mice

Zi Guo Yuan, Xiu Ming Li, Yasser Saad Mahmmod, Xiao Hu Wang, Hui Juan Xu, Xiu Xiang Zhang

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Seoul virus (SEOV), a member of hantavirus genus, is one of the causative agents of hemorrhagic fever with renal syndrome (HFRS) and afflicts tens of thousands of people annually. In this paper, we evaluate the immune response induced by a replication-competent recombinant canine adenovirus type 2 expressing the Gn protein of SEOV (rCAV-2-Gn) in BALB/c mice. Sera from immunized mice contained neutralizing antibodies that could specifically recognize SEOV and neutralize its infectivity in vitro. Moreover, the recombinant virus induced complete protection against a lethal challenge with the highly virulent SEOV strain CC-2. Protective level neutralizing antibodies were maintained for at least 20 weeks. The efficacy of the recombinant was similar to that induced by a currently available inactivated HFRS vaccine. This recombinant virus is therefore a potential alternative to the inactivated vaccine. Crown

Original languageEnglish (US)
Pages (from-to)5247-5251
Number of pages5
JournalVaccine
Volume27
Issue number38
DOIs
StatePublished - Aug 20 2009

Keywords

  • Canine adenovirus type 2
  • Gn
  • Immunity
  • Mice
  • Seoul virus

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