A structural and functional model for dioxygenases with a 2-His-1-carboxylate triad

Paul D. Oldenburg; Chun Yen Ke; A. Alex Tipton; Albert A. Shteinman; Lawrence Que

doi:10.1002/anie.200603486

A structural and functional model for dioxygenases with a 2-His-1-carboxylate triad

Paul D. Oldenburg, Chun Yen Ke, A. Alex Tipton, Albert A. Shteinman, Lawrence Que

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

(Chemical Equation Presented) An attractive model: The iron complex shown on the left models the 2-His-1-carboxylate active sites of Rieske dioxygenases both in terms of structure and function. ¹⁸O-labeling studies of olefin dihydroxylation support the involvement of a high-valent iron-oxo species.

Original language	English (US)
Pages (from-to)	7975-7978
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	47
DOIs	https://doi.org/10.1002/anie.200603486
State	Published - Dec 4 2006

Keywords

Dihydroxylation
Dioxygenases
Enzyme models
Epoxidation
Oxidation

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AU - Shteinman, Albert A.

AU - Que, Lawrence

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KW - Dihydroxylation

KW - Dioxygenases

KW - Enzyme models

KW - Epoxidation

KW - Oxidation

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A structural and functional model for dioxygenases with a 2-His-1-carboxylate triad

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