A study of tobacco carcinogenesis. XV. Effects of N′-nitrosonornicotine and N′-nitrosoanabasine in Syrian golden hamsters

Jörn Hilfrich; Stephen S. Hecht; Dietrich Hoffmann

doi:10.1016/S0304-3835(77)80007-4

A study of tobacco carcinogenesis. XV. Effects of N′-nitrosonornicotine and N′-nitrosoanabasine in Syrian golden hamsters

Jörn Hilfrich, Stephen S. Hecht, Dietrich Hoffmann

Laboratory Medicine and Pathology

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Abstract

N′-Nitrosonornicotine (NNN) and N′-nitrosoanabasine (NAB) were synthesized and injected subcutaneously three times weekly in male and female Syrian golden hamsters for 25 weeks (total dose 375 mg). N-Nitrosopiperidine (NPD) served as positive control (total dose 150 mg). Within 83 weeks 12 out of 19 hamsters given NNN had developed tracheal tumors, 1 had a carcinoma of the nasal cavity. During the same time none of the hamsters given NAB developed tumors, whereas all 20 hamsters given NPD developed tracheal tumors and about 50% had additional neoplasms in the nasal cavity. Under the described conditions and in comparison to NPD, NNN appears to be a moderately active tumorigenic agent in the upper respiratory tract of Syrian hamsters, whereas NAB is inactive.

Original language	English (US)
Pages (from-to)	169-175
Number of pages	7
Journal	Cancer Letters
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3835(77)80007-4
State	Published - Jan 1977

Bibliographical note

Funding Information:
The authors thank Mr Chang Choi for his excellent assistance. This study was supported by Core Cancer Center Program CA-I7613 and by National Cancer Institute ConJxact N01-CP-55666.

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title = "A study of tobacco carcinogenesis. XV. Effects of N′-nitrosonornicotine and N′-nitrosoanabasine in Syrian golden hamsters",

abstract = "N′-Nitrosonornicotine (NNN) and N′-nitrosoanabasine (NAB) were synthesized and injected subcutaneously three times weekly in male and female Syrian golden hamsters for 25 weeks (total dose 375 mg). N-Nitrosopiperidine (NPD) served as positive control (total dose 150 mg). Within 83 weeks 12 out of 19 hamsters given NNN had developed tracheal tumors, 1 had a carcinoma of the nasal cavity. During the same time none of the hamsters given NAB developed tumors, whereas all 20 hamsters given NPD developed tracheal tumors and about 50% had additional neoplasms in the nasal cavity. Under the described conditions and in comparison to NPD, NNN appears to be a moderately active tumorigenic agent in the upper respiratory tract of Syrian hamsters, whereas NAB is inactive.",

author = "J{\"o}rn Hilfrich and Hecht, {Stephen S.} and Dietrich Hoffmann",

note = "Funding Information: The authors thank Mr Chang Choi for his excellent assistance. This study was supported by Core Cancer Center Program CA-I7613 and by National Cancer Institute ConJxact N01-CP-55666.",

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AU - Hilfrich, Jörn

AU - Hecht, Stephen S.

AU - Hoffmann, Dietrich

N1 - Funding Information: The authors thank Mr Chang Choi for his excellent assistance. This study was supported by Core Cancer Center Program CA-I7613 and by National Cancer Institute ConJxact N01-CP-55666.

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N2 - N′-Nitrosonornicotine (NNN) and N′-nitrosoanabasine (NAB) were synthesized and injected subcutaneously three times weekly in male and female Syrian golden hamsters for 25 weeks (total dose 375 mg). N-Nitrosopiperidine (NPD) served as positive control (total dose 150 mg). Within 83 weeks 12 out of 19 hamsters given NNN had developed tracheal tumors, 1 had a carcinoma of the nasal cavity. During the same time none of the hamsters given NAB developed tumors, whereas all 20 hamsters given NPD developed tracheal tumors and about 50% had additional neoplasms in the nasal cavity. Under the described conditions and in comparison to NPD, NNN appears to be a moderately active tumorigenic agent in the upper respiratory tract of Syrian hamsters, whereas NAB is inactive.

AB - N′-Nitrosonornicotine (NNN) and N′-nitrosoanabasine (NAB) were synthesized and injected subcutaneously three times weekly in male and female Syrian golden hamsters for 25 weeks (total dose 375 mg). N-Nitrosopiperidine (NPD) served as positive control (total dose 150 mg). Within 83 weeks 12 out of 19 hamsters given NNN had developed tracheal tumors, 1 had a carcinoma of the nasal cavity. During the same time none of the hamsters given NAB developed tumors, whereas all 20 hamsters given NPD developed tracheal tumors and about 50% had additional neoplasms in the nasal cavity. Under the described conditions and in comparison to NPD, NNN appears to be a moderately active tumorigenic agent in the upper respiratory tract of Syrian hamsters, whereas NAB is inactive.

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A study of tobacco carcinogenesis. XV. Effects of N′-nitrosonornicotine and N′-nitrosoanabasine in Syrian golden hamsters

Abstract

Bibliographical note

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