A study of toxicity and differential gene expression in murine liver following exposure to anti-malarial drugs: Amodiaquine and sulphadoxine- pyrimethamine

Agriculture & Biology

• sulfadoxine 100%
• pyrimethamine 90%
• antimalarials 72%
• toxicity testing 61%
• gene expression 35%
• liver 34%
• mice 34%
• therapeutics 26%
• drug toxicity 23%
• hepatotoxicity 20%
• biomarkers 15%
• falciparum malaria 13%
• oxidative stress 13%
• drugs 11%
• chloroquine 10%
• hepatitis 10%
• Sub-Saharan Africa 9%
• DNA microarrays 9%
• clinical trials 9%
• histology 8%
• drug therapy 8%
• antioxidant enzymes 7%
• transcriptomics 7%
• catalase 6%
• superoxide dismutase 6%
• history 6%
• toxicity 5%
• tissues 3%
• genes 2%
• methodology 2%

Medicine & Life Sciences

• Amodiaquine 90%
• pyrimethamine drug combination fanasil 83%
• Antimalarials 65%
• Gene Expression 35%
• Liver 30%
• Pharmaceutical Preparations 24%
• Drug-Related Side Effects and Adverse Reactions 13%
• Oxidative Stress 10%
• Biomarkers 9%
• Agranulocytosis 9%
• Falciparum Malaria 8%
• Chloroquine 8%
• Africa South of the Sahara 8%
• Glutathione Peroxidase 7%
• Oligonucleotide Array Sequence Analysis 7%
• Therapeutics 7%
• Catalase 7%
• Hepatitis 6%
• Superoxide Dismutase 6%
• Serum 6%
• Histology 5%
• History 5%
• Poisons 5%
• Antioxidants 5%
• Clinical Studies 5%
• Enzymes 4%
• Genes 2%