A supramolecular synthon approach was exploited to design amorphous solid dispersions (ASDs) of drugs containing an amino aromatic nitrogen moiety and a polyacrylic acid polymer. The interaction between a drug and polymer was confirmed by differential scanning calorimetry, spectroscopy (IR and 15N NMR), and X-ray crystallography. The interaction decreased the molecular mobility, conferred exceptional physical stability and enhanced the drug dissolution.
Bibliographical noteFunding Information:
This research was partially supported by the William and Mildred Peters Endowment Fund. Parts of this work were carried out in the Characterization Facility, University of Minnesota, a member of the National Science Foundation-funded Materials Research Facilities Network. Solid-state NMR experiments were carried out at the Minnesota NMR Center, University of Minnesota. Anasuya Sahoo is acknowledged for her help.
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