A synthetic metabolic pathway for production of the platform chemical isobutyric acid

Kechun Zhang, Adam P. Woodruff, Mingyong Xiong, Jun Zhou, Yogesh K. Dhande

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Go green: Isobutyric acid is a high-volume industrial chemical produced from non-sustainable petroleum feedstocks and toxic materials. A synthetic metabolic pathway is constructed in E. coli to enable the biosynthesis of this compound from glucose, a renewable carbon source. The biosynthetic approach is an attractive option from both an economical and environmental point of view.

Original languageEnglish (US)
Pages (from-to)1068-1070
Number of pages3
JournalChemSusChem
Volume4
Issue number8
DOIs
StatePublished - Aug 22 2011

Keywords

  • biosynthesis
  • enzymes
  • isobutyrate
  • metabolism
  • renewable resources

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