A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation

Melanie S. Vacchio; Thomas Ciucci; Yayi Gao; Masashi Watanabe; Mariah Balmaceno-Criss; Mitchell T. McGinty; Allan Huang; Qi Xiao; Cameron McConkey; Yongmei Zhao; Jyoti Shetty; Bao Tran; Marion Pepper; Golnaz Vahedi; Marc K. Jenkins; Dorian B. McGavern; Rémy Bosselut

doi:10.1016/j.immuni.2019.06.023

A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation

Melanie S. Vacchio, Thomas Ciucci, Yayi Gao, Masashi Watanabe, Mariah Balmaceno-Criss, Mitchell T. McGinty, Allan Huang, Qi Xiao, Cameron McConkey, Yongmei Zhao, Jyoti Shetty, Bao Tran, Marion Pepper, Golnaz Vahedi, Marc K. Jenkins, Dorian B. McGavern, Rémy Bosselut

Microbiology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The transcription factor Thpok is essential for the development of CD4⁺ T cells. Vacchio et al. show that in mature T cells, Thpok drives the expression of the transcriptional regulators Bcl6 and Maf to promote the differentiation of CD4⁺ T cells into T follicular helper (Tfh) cells, thus linking the CD4⁺ lineage to Tfh cell differentiation.

Original language	English (US)
Pages (from-to)	465-478.e6
Journal	Immunity
Volume	51
Issue number	3
DOIs	https://doi.org/10.1016/j.immuni.2019.06.023
State	Published - Sep 17 2019

Keywords

Bcl6
CD4 T cells
Maf
Thpok
follicular helper T cells
germinal center reaction

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

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Vacchio, M. S., Ciucci, T., Gao, Y., Watanabe, M., Balmaceno-Criss, M., McGinty, M. T., Huang, A., Xiao, Q., McConkey, C., Zhao, Y., Shetty, J., Tran, B., Pepper, M., Vahedi, G., Jenkins, M. K., McGavern, D. B., & Bosselut, R. (2019). A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation. Immunity, 51(3), 465-478.e6. https://doi.org/10.1016/j.immuni.2019.06.023

A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation. / Vacchio, Melanie S.; Ciucci, Thomas; Gao, Yayi; Watanabe, Masashi; Balmaceno-Criss, Mariah; McGinty, Mitchell T.; Huang, Allan; Xiao, Qi; McConkey, Cameron; Zhao, Yongmei; Shetty, Jyoti; Tran, Bao; Pepper, Marion; Vahedi, Golnaz; Jenkins, Marc K.; McGavern, Dorian B.; Bosselut, Rémy.

In: Immunity, Vol. 51, No. 3, 17.09.2019, p. 465-478.e6.

Research output: Contribution to journal › Article › peer-review

Vacchio, MS, Ciucci, T, Gao, Y, Watanabe, M, Balmaceno-Criss, M, McGinty, MT, Huang, A, Xiao, Q, McConkey, C, Zhao, Y, Shetty, J, Tran, B, Pepper, M, Vahedi, G, Jenkins, MK, McGavern, DB & Bosselut, R 2019, 'A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation', Immunity, vol. 51, no. 3, pp. 465-478.e6. https://doi.org/10.1016/j.immuni.2019.06.023

Vacchio, Melanie S. ; Ciucci, Thomas ; Gao, Yayi ; Watanabe, Masashi ; Balmaceno-Criss, Mariah ; McGinty, Mitchell T. ; Huang, Allan ; Xiao, Qi ; McConkey, Cameron ; Zhao, Yongmei ; Shetty, Jyoti ; Tran, Bao ; Pepper, Marion ; Vahedi, Golnaz ; Jenkins, Marc K. ; McGavern, Dorian B. ; Bosselut, Rémy. / A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation. In: Immunity. 2019 ; Vol. 51, No. 3. pp. 465-478.e6.

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