A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation

Melanie S. Vacchio; Thomas Ciucci; Yayi Gao; Masashi Watanabe; Mariah Balmaceno-Criss; Mitchell T. McGinty; Allan Huang; Qi Xiao; Cameron McConkey; Yongmei Zhao; Jyoti Shetty; Bao Tran; Marion Pepper; Golnaz Vahedi; Marc K. Jenkins; Dorian B. McGavern; Rémy Bosselut

doi:10.1016/j.immuni.2019.06.023

A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation

Melanie S. Vacchio, Thomas Ciucci, Yayi Gao, Masashi Watanabe, Mariah Balmaceno-Criss, Mitchell T. McGinty, Allan Huang, Qi Xiao, Cameron McConkey, Yongmei Zhao, Jyoti Shetty, Bao Tran, Marion Pepper, Golnaz Vahedi, Marc K. Jenkins, Dorian B. McGavern, Rémy Bosselut

Microbiology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The transcription factor Thpok is essential for the development of CD4⁺ T cells. Vacchio et al. show that in mature T cells, Thpok drives the expression of the transcriptional regulators Bcl6 and Maf to promote the differentiation of CD4⁺ T cells into T follicular helper (Tfh) cells, thus linking the CD4⁺ lineage to Tfh cell differentiation.

Original language	English (US)
Pages (from-to)	465-478.e6
Journal	Immunity
Volume	51
Issue number	3
DOIs	https://doi.org/10.1016/j.immuni.2019.06.023
State	Published - Sep 17 2019

Bibliographical note

Publisher Copyright:
© 2019

Keywords

Bcl6
CD4 T cells
Maf
Thpok
follicular helper T cells
germinal center reaction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/j.immuni.2019.06.023

OpenUrl availability

Full text

Cite this

Vacchio, M. S., Ciucci, T., Gao, Y., Watanabe, M., Balmaceno-Criss, M., McGinty, M. T., Huang, A., Xiao, Q., McConkey, C., Zhao, Y., Shetty, J., Tran, B., Pepper, M., Vahedi, G., Jenkins, M. K., McGavern, D. B., & Bosselut, R. (2019). A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation. Immunity, 51(3), 465-478.e6. https://doi.org/10.1016/j.immuni.2019.06.023

Vacchio, MS, Ciucci, T, Gao, Y, Watanabe, M, Balmaceno-Criss, M, McGinty, MT, Huang, A, Xiao, Q, McConkey, C, Zhao, Y, Shetty, J, Tran, B, Pepper, M, Vahedi, G, Jenkins, MK, McGavern, DB & Bosselut, R 2019, 'A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation', Immunity, vol. 51, no. 3, pp. 465-478.e6. https://doi.org/10.1016/j.immuni.2019.06.023

@article{bca0293792fd481fabeaf28fd83fa144,

title = "A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation",

abstract = "The transcription factor Thpok is essential for the development of CD4+ T cells. Vacchio et al. show that in mature T cells, Thpok drives the expression of the transcriptional regulators Bcl6 and Maf to promote the differentiation of CD4+ T cells into T follicular helper (Tfh) cells, thus linking the CD4+ lineage to Tfh cell differentiation.",

keywords = "Bcl6, CD4 T cells, Maf, Thpok, follicular helper T cells, germinal center reaction",

author = "Vacchio, {Melanie S.} and Thomas Ciucci and Yayi Gao and Masashi Watanabe and Mariah Balmaceno-Criss and McGinty, {Mitchell T.} and Allan Huang and Qi Xiao and Cameron McConkey and Yongmei Zhao and Jyoti Shetty and Bao Tran and Marion Pepper and Golnaz Vahedi and Jenkins, {Marc K.} and McGavern, {Dorian B.} and R{\'e}my Bosselut",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = sep,

day = "17",

doi = "10.1016/j.immuni.2019.06.023",

language = "English (US)",

volume = "51",

pages = "465--478.e6",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation

AU - Vacchio, Melanie S.

AU - Ciucci, Thomas

AU - Gao, Yayi

AU - Watanabe, Masashi

AU - Balmaceno-Criss, Mariah

AU - McGinty, Mitchell T.

AU - Huang, Allan

AU - Xiao, Qi

AU - McConkey, Cameron

AU - Zhao, Yongmei

AU - Shetty, Jyoti

AU - Tran, Bao

AU - Pepper, Marion

AU - Vahedi, Golnaz

AU - Jenkins, Marc K.

AU - McGavern, Dorian B.

AU - Bosselut, Rémy

PY - 2019/9/17

Y1 - 2019/9/17

N2 - The transcription factor Thpok is essential for the development of CD4+ T cells. Vacchio et al. show that in mature T cells, Thpok drives the expression of the transcriptional regulators Bcl6 and Maf to promote the differentiation of CD4+ T cells into T follicular helper (Tfh) cells, thus linking the CD4+ lineage to Tfh cell differentiation.

AB - The transcription factor Thpok is essential for the development of CD4+ T cells. Vacchio et al. show that in mature T cells, Thpok drives the expression of the transcriptional regulators Bcl6 and Maf to promote the differentiation of CD4+ T cells into T follicular helper (Tfh) cells, thus linking the CD4+ lineage to Tfh cell differentiation.

KW - Bcl6

KW - CD4 T cells

KW - Maf

KW - Thpok

KW - follicular helper T cells

KW - germinal center reaction

UR - http://www.scopus.com/inward/record.url?scp=85072025926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072025926&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2019.06.023

DO - 10.1016/j.immuni.2019.06.023

M3 - Article

C2 - 31422869

AN - SCOPUS:85072025926

SN - 1074-7613

VL - 51

SP - 465-478.e6

JO - Immunity

JF - Immunity

IS - 3

ER -

A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation

Abstract

Bibliographical note

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this