Abstract
The transcription factor Thpok is essential for the development of CD4+ T cells. Vacchio et al. show that in mature T cells, Thpok drives the expression of the transcriptional regulators Bcl6 and Maf to promote the differentiation of CD4+ T cells into T follicular helper (Tfh) cells, thus linking the CD4+ lineage to Tfh cell differentiation.
Original language | English (US) |
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Pages (from-to) | 465-478.e6 |
Journal | Immunity |
Volume | 51 |
Issue number | 3 |
DOIs | |
State | Published - Sep 17 2019 |
Keywords
- Bcl6
- CD4 T cells
- Maf
- Thpok
- follicular helper T cells
- germinal center reaction
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, N.I.H., Intramural