TY - JOUR
T1 - A Tomato-Based, Lycopene-Containing Intervention for Androgen-Independent Prostate Cancer
T2 - Results of a Phase II Study from The North Central Cancer Treatment Group
AU - Jatoi, Aminah
AU - Burch, Patrick
AU - Hillman, David
AU - Vanyo, Joanne M.
AU - Dakhil, Shaker
AU - Nikcevich, Daniel
AU - Rowland, Kendrith
AU - Morton, Roscoe
AU - Flynn, Patrick J.
AU - Young, Charles
AU - Tan, Winston
PY - 2007/2
Y1 - 2007/2
N2 - Objectives: Tomatoes are rich in lycopene. This study explored the efficacy of a lycopene-rich tomato product in androgen-independent prostate cancer and the reasons patients participated in an "alternative medicine" study. Methods: This Phase II study evaluated 46 patients with androgen-independent prostate cancer. All were asymptomatic and had serum prostate-specific antigen elevation despite hormonal manipulation. All patients completed a questionnaire on their motivations for enrolling in an "alternative medicine" study. Patients were prescribed a lycopene-rich tomato supplement at a lycopene dose of 15 mg twice daily. Results: One patient manifested a tumor response with a 50% or greater confirmed decline in serum prostate-specific antigen level, yielding a response rate of 2%. Lycopene was well tolerated, but 1 patient died of a cancer-related hemorrhage, and 1 had grade 4 diarrhea. Grade 1 or 2 events included diarrhea in 18, nausea in 12, abdominal distension in 8, flatulence in 2, vomiting in 2, anorexia in 1, and dyspepsia in 1. The reasons for entering the trial are discussed and were overall positive. Conclusions: Lycopene, as prescribed in our study, did not appear effective for androgen-independent prostate cancer. The patients' reasons for enrolling in this trial were positive and realistic.
AB - Objectives: Tomatoes are rich in lycopene. This study explored the efficacy of a lycopene-rich tomato product in androgen-independent prostate cancer and the reasons patients participated in an "alternative medicine" study. Methods: This Phase II study evaluated 46 patients with androgen-independent prostate cancer. All were asymptomatic and had serum prostate-specific antigen elevation despite hormonal manipulation. All patients completed a questionnaire on their motivations for enrolling in an "alternative medicine" study. Patients were prescribed a lycopene-rich tomato supplement at a lycopene dose of 15 mg twice daily. Results: One patient manifested a tumor response with a 50% or greater confirmed decline in serum prostate-specific antigen level, yielding a response rate of 2%. Lycopene was well tolerated, but 1 patient died of a cancer-related hemorrhage, and 1 had grade 4 diarrhea. Grade 1 or 2 events included diarrhea in 18, nausea in 12, abdominal distension in 8, flatulence in 2, vomiting in 2, anorexia in 1, and dyspepsia in 1. The reasons for entering the trial are discussed and were overall positive. Conclusions: Lycopene, as prescribed in our study, did not appear effective for androgen-independent prostate cancer. The patients' reasons for enrolling in this trial were positive and realistic.
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U2 - 10.1016/j.urology.2006.10.019
DO - 10.1016/j.urology.2006.10.019
M3 - Article
C2 - 17320666
AN - SCOPUS:33847049097
SN - 0090-4295
VL - 69
SP - 289
EP - 294
JO - Urology
JF - Urology
IS - 2
ER -