A toxicologic and dermatologic assessment of cyclic and non-cyclic terpene alcohols when used as fragrance ingredients

Agriculture & Biology

• terpenoids 77%
• alcohols 65%
• ingredients 65%
• odors 63%
• no observed adverse effect level 29%
• body weight 27%
• citronellol 20%
• toxicity 19%
• developmental toxicity 18%
• linalool 16%
• genotoxicity 16%
• toxicity testing 15%
• lethal dose 50 14%
• in vitro studies 14%
• bioavailability 14%
• acute dermal toxicity 13%
• urine 12%
• dosage 11%
• mouth 11%
• acute oral toxicity 11%
• eye irritation 10%
• phototoxicity 10%
• oral exposure 10%
• farnesol 10%
• polar compounds 9%
• reproductive toxicology 9%
• geraniol 9%
• dermis 8%
• dermatitis 8%
• liver 8%
• hydroperoxides 8%
• acids 8%
• chromosome aberrations 7%
• epidermis (animal) 7%
• food consumption 7%
• aldehydes 7%
• purity 6%
• biochemical pathways 6%
• adverse effects 5%
• excretion 5%
• feces 5%
• skin (animal) 5%
• oxidation 5%
• kidneys 5%
• mutation 5%
• rabbits 4%
• metabolites 4%
• metabolism 4%
• organisms 4%
• tissues 3%
• testing 2%

Medicine & Life Sciences

• Terpenes 98%
• Odorants 85%
• Alcohols 60%
• 3,7-dimethyl-7-octen-1-ol 39%
• Body Weight 34%
• No-Observed-Adverse-Effect Level 32%
• Photoallergic Dermatitis 26%
• linalool 25%
• 3,7-dimethyl-4,6-octadien-3-ol 20%
• Lethal Dose 50 18%
• 6,6-dimethyl-2-methylenebicyclo(3.1.1)heptan-3-ol 17%
• sclareol 16%
• citronellol 14%
• bisabolol 14%
• Biological Availability 14%
• Skin 13%
• geraniol 13%
• Farnesol 12%
• Acids 12%
• Phototoxic Dermatitis 11%
• 2-Propanol 10%
• In Vitro Techniques 10%
• Glucuronides 9%
• Aldehydes 9%
• Subcutaneous Tissue 8%
• Dermatitis 8%
• Dermis 8%
• Liver 8%
• Feces 8%
• Metabolic Networks and Pathways 8%
• Hydrogen Peroxide 8%
• Epidermis 7%
• Chromosome Aberrations 7%
• Rabbits 5%
• Food 5%
• Mothers 5%
• Eye 4%
• Safety 4%
• Mutation 4%
• Kidney 4%

Chemical Compounds

• Fragrance 100%
• Alcohol 48%
• Weight 32%
• Linalool 25%
• Genotoxicity 24%
• Developmental 24%
• Dose 23%
• Sensitization 21%
• Acute Toxicity Dermal 21%
• Bioavailability 19%
• Sclareol 17%
• Acute Toxicity Oral 16%
• Farnesol 15%
• Citronellol 14%
• Phototoxic 14%
• Unsaturated Alcohol 13%
• Geraniol 13%
• Sensitizing 12%
• Primary Alcohol 11%
• Secondary Alcohol 10%
• Hydroperoxide 10%
• Safety 8%
• Mutation 8%
• Ultraviolet Spectrum 8%
• Metabolic 8%
• Pharmacological Metabolism 7%
• Food 7%
• Metabolite 7%
• Acid 6%
• Aldehyde 6%
• Purity 5%
• Oxidation Reaction 4%
• Amount 4%