A whole-genome scan for stroke or myocardial infarction in family blood pressure program families

Richard Sherva, Michael B. Miller, James S. Pankow, Steven C. Hunt, Eric Boerwinkle, Thomas H. Mosley, Alan B. Weder, J. David Curb, Amy Luke, Alanna C. Morrison, Myriam Fornage, Donna K. Arnett

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

BACKGROUND AND PURPOSE - Atherothrombotic diseases, including stroke and myocardial infarction, share a common pathogenesis. Chromosomal regions have been linked to atherothrombotic diseases in family studies, and association studies have identified candidate gene polymorphisms that affect the risk of stroke and/or myocardial infarction. Using data from the Family Blood Pressure Program, we tested for chromosomal regions linked to the composite phenotype of stroke or myocardial infarction in a large set of hypertensive families. METHODS - Nonparametric linkage analysis was implemented in MERLIN, which tests for excess allele-sharing among affected siblings. Empirical distributions based on gene dropping simulations were constructed for each test statistic, and the -log10 of the associated probability values were compared. RESULTS - Analyses were based on 9607 individuals in 226 black, 395 Hispanic, and 207 white families; 106 families had multiple affected individuals. Several regions showed linkage to stroke or myocardial infarction, most significantly in Hispanics on chromosomes 2p21 (-log10 P=3.0) and 7q21.1 (-log10 P=2.8), 9q32 in blacks and Hispanics (-log10 P=3.0), 11p13 in blacks (-log10 P=2.1), and 12q24.33 in whites (-log10 P=3.0). CONCLUSIONS - There is statistically significant evidence for loci affecting stroke or myocardial infarction on chromosomes 2, 9, and 12.

Original languageEnglish (US)
Pages (from-to)1115-1120
Number of pages6
JournalStroke
Volume39
Issue number4
DOIs
StatePublished - Apr 2008

Keywords

  • Cerebrovascular accident
  • Epidemiology
  • LOD score
  • Linkage (genetics)
  • Myocardial infarction

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