Abl2/Abl-related gene stabilizes actin filaments, stimulates actin branching by actin-related protein 2/3 complex, and promotes actin filament severing by cofilin

Naomi Courtemanche; Stacey M. Gifford; Mark A. Simpson; Thomas D. Pollard; Anthony J. Koleske

doi:10.1074/jbc.M114.608117

Abl2/Abl-related gene stabilizes actin filaments, stimulates actin branching by actin-related protein 2/3 complex, and promotes actin filament severing by cofilin

Naomi Courtemanche, Stacey M. Gifford, Mark A. Simpson, Thomas D. Pollard, Anthony J. Koleske

Genetics, Cell Biology and Development (CBS)

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Background: Arg/Abl2 has two actin-binding domains, but how they influence actin filaments was unknown. Results: Arg and cortactin cooperatively stabilize actin filaments; Arg enhances Arp2/3 complex activation and stimulates severing by cofilin. Conclusion: Arg directly regulates actin filament stability, branching, and severing, which are modulated by cortactin. Significance: These activities may underlie the control of actin-based cellular structures by Arg.

Original language	English (US)
Pages (from-to)	4038-4046
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	290
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M114.608117
State	Published - Feb 13 2015

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.

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Abl2/Abl-related gene stabilizes actin filaments, stimulates actin branching by actin-related protein 2/3 complex, and promotes actin filament severing by cofilin. / Courtemanche, Naomi; Gifford, Stacey M.; Simpson, Mark A. et al.
In: Journal of Biological Chemistry, Vol. 290, No. 7, 13.02.2015, p. 4038-4046.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background: Arg/Abl2 has two actin-binding domains, but how they influence actin filaments was unknown. Results: Arg and cortactin cooperatively stabilize actin filaments; Arg enhances Arp2/3 complex activation and stimulates severing by cofilin. Conclusion: Arg directly regulates actin filament stability, branching, and severing, which are modulated by cortactin. Significance: These activities may underlie the control of actin-based cellular structures by Arg.",

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AU - Simpson, Mark A.

AU - Pollard, Thomas D.

AU - Koleske, Anthony J.

PY - 2015/2/13

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Abl2/Abl-related gene stabilizes actin filaments, stimulates actin branching by actin-related protein 2/3 complex, and promotes actin filament severing by cofilin

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