Abnormal flow adhesion of sickle red blood cells to human placental trophoblast extracellular matrix

Yann Lamarre; Stéphane Petres; Marie Dominique Hardy-Dessources; Stéphane Sinnapah; Marc Romana; Sandrine Laurance; Nathalie Lemonne; Jürg Gysin; Philippe Connes

doi:10.3233/CH-2011-1525

Abnormal flow adhesion of sickle red blood cells to human placental trophoblast extracellular matrix

Yann Lamarre, Stéphane Petres, Marie Dominique Hardy-Dessources, Stéphane Sinnapah, Marc Romana, Sandrine Laurance, Nathalie Lemonne, Jürg Gysin, Philippe Connes

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Pregnancy in sickle cell disease (SCD) has been associated with increased complications such as vaso-occlusive crises, severe anemia and foetal loss. It has been proposed that the sickling of red blood cells (RBCs) inside the placenta circulation could participate to these complications. The present study investigated the adhesion of sickle RBCs on human trophoblast-derived cell and its extracellular matrix. Results demonstrated 1) similar adhesion of sickle RBCs and healthy RBCs to trophoblast but 2) a greater adhesion of sickle RBCs to the extracellular matrix of trophoblasts as compared with healthy RBCs. This greater adhesion could partly involve the Lu/BCAM glycoproteins and could participate to the complications reported in SCD pregnant women.

Original language	English (US)
Pages (from-to)	229-234
Number of pages	6
Journal	Clinical hemorheology and microcirculation
Volume	51
Issue number	3
DOIs	https://doi.org/10.3233/CH-2011-1525
State	Published - 2012
Externally published	Yes

Keywords

Sickle red cells
flow adhesion
pregnancy complications

Access

10.3233/CH-2011-1525

OpenUrl availability

Full text

Cite this

@article{8025ff179f6e4ad680c85c37097f6070,

title = "Abnormal flow adhesion of sickle red blood cells to human placental trophoblast extracellular matrix",

abstract = "Pregnancy in sickle cell disease (SCD) has been associated with increased complications such as vaso-occlusive crises, severe anemia and foetal loss. It has been proposed that the sickling of red blood cells (RBCs) inside the placenta circulation could participate to these complications. The present study investigated the adhesion of sickle RBCs on human trophoblast-derived cell and its extracellular matrix. Results demonstrated 1) similar adhesion of sickle RBCs and healthy RBCs to trophoblast but 2) a greater adhesion of sickle RBCs to the extracellular matrix of trophoblasts as compared with healthy RBCs. This greater adhesion could partly involve the Lu/BCAM glycoproteins and could participate to the complications reported in SCD pregnant women.",

keywords = "Sickle red cells, flow adhesion, pregnancy complications",

author = "Yann Lamarre and St{\'e}phane Petres and Hardy-Dessources, {Marie Dominique} and St{\'e}phane Sinnapah and Marc Romana and Sandrine Laurance and Nathalie Lemonne and J{\"u}rg Gysin and Philippe Connes",

year = "2012",

doi = "10.3233/CH-2011-1525",

language = "English (US)",

volume = "51",

pages = "229--234",

journal = "Clinical hemorheology and microcirculation",

issn = "1386-0291",

publisher = "IOS Press",

number = "3",

}

TY - JOUR

T1 - Abnormal flow adhesion of sickle red blood cells to human placental trophoblast extracellular matrix

AU - Lamarre, Yann

AU - Petres, Stéphane

AU - Hardy-Dessources, Marie Dominique

AU - Sinnapah, Stéphane

AU - Romana, Marc

AU - Laurance, Sandrine

AU - Lemonne, Nathalie

AU - Gysin, Jürg

AU - Connes, Philippe

PY - 2012

Y1 - 2012

N2 - Pregnancy in sickle cell disease (SCD) has been associated with increased complications such as vaso-occlusive crises, severe anemia and foetal loss. It has been proposed that the sickling of red blood cells (RBCs) inside the placenta circulation could participate to these complications. The present study investigated the adhesion of sickle RBCs on human trophoblast-derived cell and its extracellular matrix. Results demonstrated 1) similar adhesion of sickle RBCs and healthy RBCs to trophoblast but 2) a greater adhesion of sickle RBCs to the extracellular matrix of trophoblasts as compared with healthy RBCs. This greater adhesion could partly involve the Lu/BCAM glycoproteins and could participate to the complications reported in SCD pregnant women.

AB - Pregnancy in sickle cell disease (SCD) has been associated with increased complications such as vaso-occlusive crises, severe anemia and foetal loss. It has been proposed that the sickling of red blood cells (RBCs) inside the placenta circulation could participate to these complications. The present study investigated the adhesion of sickle RBCs on human trophoblast-derived cell and its extracellular matrix. Results demonstrated 1) similar adhesion of sickle RBCs and healthy RBCs to trophoblast but 2) a greater adhesion of sickle RBCs to the extracellular matrix of trophoblasts as compared with healthy RBCs. This greater adhesion could partly involve the Lu/BCAM glycoproteins and could participate to the complications reported in SCD pregnant women.

KW - Sickle red cells

KW - flow adhesion

KW - pregnancy complications

UR - http://www.scopus.com/inward/record.url?scp=84863903874&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863903874&partnerID=8YFLogxK

U2 - 10.3233/CH-2011-1525

DO - 10.3233/CH-2011-1525

M3 - Article

C2 - 22240382

AN - SCOPUS:84863903874

SN - 1386-0291

VL - 51

SP - 229

EP - 234

JO - Clinical hemorheology and microcirculation

JF - Clinical hemorheology and microcirculation

IS - 3

ER -

Abnormal flow adhesion of sickle red blood cells to human placental trophoblast extracellular matrix

Abstract

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this