TY - JOUR
T1 - About 8-hour variation of circulating human endothelin-1
AU - Herold, Manfred
AU - Cornélissen, Germaine
AU - Loeckinger, Alexander
AU - Koeberle, Dieter
AU - Koenig, Paul
AU - Halberg, Franz
PY - 1998/5
Y1 - 1998/5
N2 - Plasma endothelin-1 (ET-1) and cortisol were measured around the clock at hourly intervals on 7 clinically healthy, diurnally active, nocturnally resting subjects 22-27 years of age. The circadian rhythm in cortisol is demonstrated for each subject (p ≤ 0.020) as well as on a group basis (p = 0.002), peaking in the morning. By contrast, the circadian variation of ET-1 is statistically significant in only one of the subjects, and it is not detected for the group as a whole (p > 0.20). Instead, ET-1 is characterized by an about 8-h component (p < 0.001) that is not found for cortisol.
AB - Plasma endothelin-1 (ET-1) and cortisol were measured around the clock at hourly intervals on 7 clinically healthy, diurnally active, nocturnally resting subjects 22-27 years of age. The circadian rhythm in cortisol is demonstrated for each subject (p ≤ 0.020) as well as on a group basis (p = 0.002), peaking in the morning. By contrast, the circadian variation of ET-1 is statistically significant in only one of the subjects, and it is not detected for the group as a whole (p > 0.20). Instead, ET-1 is characterized by an about 8-h component (p < 0.001) that is not found for cortisol.
KW - Circadian
KW - Circaoctohoran
KW - ET- 1
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U2 - 10.1016/S0196-9781(98)00035-7
DO - 10.1016/S0196-9781(98)00035-7
M3 - Article
C2 - 9663446
AN - SCOPUS:0345404490
SN - 0196-9781
VL - 19
SP - 821
EP - 825
JO - Peptides
JF - Peptides
IS - 5
ER -