A class of proteins dubbed pipmodullns bind to and sequester the phospholipid PIP2 in the plasma membrane. Local release of PIP2 controls actin dynamics in specific subcellular regions and plays a critical role in regulating actin-based cell motility and morphogenesis.
Bibliographical noteFunding Information:
L.M.L. is supported by NIH fellowship 7F32NS10655. Work in F.B.G.'s laboratory is supported by NIH grant GM58801.