Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity

Yves Martinet, Peter B. Bitterman, Jean Francois Mornex, Gary R. Grotendorst, George R. Martin, Ronald G. Crystal

Research output: Contribution to journalArticlepeer-review

231 Scopus citations

Abstract

Current ideas about the mechanism of wound healing and the pathogenesis of atherosclerosis, pulmonary fibrosis and hepatic fibrosis suggest a central role for the mononuclear phagocyte in attracting and/or stimulating the proliferation of mesenchymal cells1-5. We demonstrate here that activated human blood monocytes, but not resting monocytes, release a mediator that attracts smooth muscle cells and cooperates with other mediators to stimulate fibroblast proliferation. This mediator is very similar to platelet-derived growth factor (PDGF): its Chromatographic properties and chemical stability are similar to those of PDGF6,7, it competes with 125I-PDGF for binding to fibroblasts and it immunoprecipitates with anti-PDGF antibodies. In parallel, stimulated monocytes, but not resting monocytes, express the c-sis proto-oncogene, a gene coding for one of the PDGF chains8,9, consistent with the concept that expression of the c-sis proto-oncogene may be involved in the ability of mononuclear phagocytes to modulate the accumulation of mesenchymal cells.

Original languageEnglish (US)
Pages (from-to)158-160
Number of pages3
JournalNature
Volume319
Issue number6049
DOIs
StatePublished - Dec 1 1986

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