Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumors

Matthew F. Mescher; Flavia E. Popescu; Michael Gerner; Chris D. Hammerbeck; Julie M. Curtsinger

doi:10.1016/j.semcancer.2007.06.008

Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumors

Matthew F. Mescher, Flavia E. Popescu, Michael Gerner, Chris D. Hammerbeck, Julie M. Curtsinger

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

Naïve CD8 T cells respond to signals provided by Ag, costimulation and cytokines by proliferating and differentiating to develop effector functions. Following initial clonal expansion, however, the cells develop activation-induced non-responsiveness (AINR), a form of anergy characterized by an inability to produce IL-2. Cells in the AINR state can carry out effector functions (cytolysis, IFN-γ production) but cannot continue to proliferate and expand in the face of persisting Ag. AINR limits the ability of activated CTL to control tumor growth but can be reversed by IL-2, provided either therapeutically or by activated CD4 T helper cells, to allow continued expansion.

Original language	English (US)
Pages (from-to)	299-308
Number of pages	10
Journal	Seminars in Cancer Biology
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.semcancer.2007.06.008
State	Published - Aug 2007

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health Grants RO1 CA088956 and PO1 AI35296.

Keywords

Anergy
CD8 T lymphocyte
Tolerance
Tumor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumors",

abstract = "Na{\"i}ve CD8 T cells respond to signals provided by Ag, costimulation and cytokines by proliferating and differentiating to develop effector functions. Following initial clonal expansion, however, the cells develop activation-induced non-responsiveness (AINR), a form of anergy characterized by an inability to produce IL-2. Cells in the AINR state can carry out effector functions (cytolysis, IFN-γ production) but cannot continue to proliferate and expand in the face of persisting Ag. AINR limits the ability of activated CTL to control tumor growth but can be reversed by IL-2, provided either therapeutically or by activated CD4 T helper cells, to allow continued expansion.",

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AU - Gerner, Michael

AU - Hammerbeck, Chris D.

AU - Curtsinger, Julie M.

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AB - Naïve CD8 T cells respond to signals provided by Ag, costimulation and cytokines by proliferating and differentiating to develop effector functions. Following initial clonal expansion, however, the cells develop activation-induced non-responsiveness (AINR), a form of anergy characterized by an inability to produce IL-2. Cells in the AINR state can carry out effector functions (cytolysis, IFN-γ production) but cannot continue to proliferate and expand in the face of persisting Ag. AINR limits the ability of activated CTL to control tumor growth but can be reversed by IL-2, provided either therapeutically or by activated CD4 T helper cells, to allow continued expansion.

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KW - Tolerance

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Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumors

Abstract

Bibliographical note

Keywords

UN SDGs

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