Activation of a specific vestibulo-olivary pathway by centripetal acceleration in rat

Galen D. Kaufman; John H. Anderson; Alvin Beitz

doi:10.1016/0006-8993(91)90637-B

Activation of a specific vestibulo-olivary pathway by centripetal acceleration in rat

Galen D. Kaufman, John H. Anderson, Alvin Beitz

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Abstract

Unanesthetized Long-Evans (pigmented) rats were subjected to 2.0 G centripetal acceleration for 90 min. Immunohistochemical analysis, using a polyclonal antibody for Fos, revealed a distinct pattern of neuronal activation in the off-axis animals in the dorsomedial cell column (DMCC) of the inferior olivary nucleus. These results are consistent with previous anatomical evidence and indicate that the DMCC is an important component in an otolith-olivocerebellar circuit which may help to define an internal spatial reference.

Original language	English (US)
Pages (from-to)	311-317
Number of pages	7
Journal	Brain Research
Volume	562
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(91)90637-B
State	Published - Oct 25 1991

Bibliographical note

Funding Information:
This work is supported by NASA/NGT-50563 and NIH Grants DC01086, NS19208, DC00ll0, DE06682, and DA06687.

Keywords

Fos
Hypergravity
Immunohistochemistry
Inferior olive
Otolith input
Vestibular system

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title = "Activation of a specific vestibulo-olivary pathway by centripetal acceleration in rat",

abstract = "Unanesthetized Long-Evans (pigmented) rats were subjected to 2.0 G centripetal acceleration for 90 min. Immunohistochemical analysis, using a polyclonal antibody for Fos, revealed a distinct pattern of neuronal activation in the off-axis animals in the dorsomedial cell column (DMCC) of the inferior olivary nucleus. These results are consistent with previous anatomical evidence and indicate that the DMCC is an important component in an otolith-olivocerebellar circuit which may help to define an internal spatial reference.",

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author = "Kaufman, {Galen D.} and Anderson, {John H.} and Alvin Beitz",

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AU - Anderson, John H.

AU - Beitz, Alvin

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N2 - Unanesthetized Long-Evans (pigmented) rats were subjected to 2.0 G centripetal acceleration for 90 min. Immunohistochemical analysis, using a polyclonal antibody for Fos, revealed a distinct pattern of neuronal activation in the off-axis animals in the dorsomedial cell column (DMCC) of the inferior olivary nucleus. These results are consistent with previous anatomical evidence and indicate that the DMCC is an important component in an otolith-olivocerebellar circuit which may help to define an internal spatial reference.

AB - Unanesthetized Long-Evans (pigmented) rats were subjected to 2.0 G centripetal acceleration for 90 min. Immunohistochemical analysis, using a polyclonal antibody for Fos, revealed a distinct pattern of neuronal activation in the off-axis animals in the dorsomedial cell column (DMCC) of the inferior olivary nucleus. These results are consistent with previous anatomical evidence and indicate that the DMCC is an important component in an otolith-olivocerebellar circuit which may help to define an internal spatial reference.

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KW - Otolith input

KW - Vestibular system

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Activation of a specific vestibulo-olivary pathway by centripetal acceleration in rat

Abstract

Bibliographical note

Keywords

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