Active renin and angiotensinogen in cardiac interstitial fluid after myocardial infarction

Alan T. Hirsch, John A. Opsahl, Mary M. Lunzer, Stephen A. Katz

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The renin-angiotensin system promotes cardiac hypertrophy after myocardial infarction. The purpose of this study was to measure renin and angiotensinogen in plasma and myocardium 10 days after myocardial infarction. Infarction involving 45±4% of left ventricular circumference with accompanying hypertrophy was induced in rats (n = 14). Plasma and myocardial renin were increased after infarction compared with sham controls (n = 8) (27.4 ± 3.2 vs. 7.5 ± 1.8 ng ANG I · ml plasma · h-1, P < 0.0002; and 8.8 ± 1.6 vs. 2.5 ± 0.1 ng ANG I·g myocardium-1 · h-1, P < 0.008, respectively). After infarction, myocardial renin was correlated with infarct size (r = 0.62, P < 0.02) and plasma renin (r = 0.55, P < 0.04). Plasma angiotensinogen decreased in infarct animals, but myocardial angiotensinogen was not different from shams (1.1 ± 0.08 vs. 2.03 ± 0.06 nM/ml plasma, P < 0.002; and 0.081 ± 0.008 vs. 0.070 ± 0.004 nM/g myocardium, respectively). In conclusion, myocardial renin increased after infarction in proportion to plasma renin and infarct size, and myocardial angiotensinogen was maintained after infarction despite decreased plasma angiotensinogen and increased levels of myocardial renin.

Original languageEnglish (US)
Pages (from-to)H1818-H1826
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume276
Issue number6 45-6
DOIs
StatePublished - Jun 1999

Keywords

  • Renin glycoforms
  • Renin-angiotensin system

Fingerprint

Dive into the research topics of 'Active renin and angiotensinogen in cardiac interstitial fluid after myocardial infarction'. Together they form a unique fingerprint.

Cite this