Activity loss of glutathione synthesis enzymes associated with human subcapsular cataract

W. B. Rathbun, A. J. Schmidt, A. M. Holleschau

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Purpose. To assess the activities of the two enzymes required for glutathione synthesis, γ-glutamylcysteine synthetase and glutathione synthetase, in various forms of human cataracts. Methods. The Cooperative Cataract Research Group cataract classification method and standard enzyme assay procedures were used. Results. An inverse relationship was shown between residual activity of each of the glutathione synthesis enzymes and degree of subcapsular cataract. A weaker inverse relationship existed between glutathione synthetase activity and supranuclear and nuclear cataracts. No other parameters yielded comparable correlations with the activity of either enzyme. Conclusions. Activity loss of the glutathione synthesis enzymes is associated with human subcapsular cataract formation.

Original languageEnglish (US)
Pages (from-to)2049-2054
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume34
Issue number6
StatePublished - Jan 1 1993

Keywords

  • γ-glutamylcysteine synthetase
  • glutathione
  • glutathione synthetase
  • human cataract
  • subcapsular cataract

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