Activity of deferasirox in Mucorales: Influences of species and exogenous iron

Russell E. Lewis, Georgios N. Pongas, Nathaniel Albert, Ronen Ben-Ami, Thomas J. Walsh, Dimitrios P. Kontoyiannis

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Differences in deferasirox susceptibility among members of the order Mucorales are unknown. Here we show that Cunninghamella bertholletiae (four isolates) and Mucor species (five isolates) display higher deferasirox MICs and minimal fungicidal concentrations compared to Rhizopus species (six isolates). Exogenous iron further attenuated the deferasirox susceptibility of Mucorales isolates with low MICs. Vital staining revealed damage to subapical compartments in susceptible strains.

Original languageEnglish (US)
Pages (from-to)411-413
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume55
Issue number1
DOIs
StatePublished - Jan 2011

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