Activity of deferasirox in Mucorales: Influences of species and exogenous iron

Russell E. Lewis; Georgios N. Pongas; Nathaniel Albert; Ronen Ben-Ami; Thomas J. Walsh; Dimitrios P. Kontoyiannis

doi:10.1128/AAC.00792-10

Activity of deferasirox in Mucorales: Influences of species and exogenous iron

Russell E. Lewis, Georgios N. Pongas, Nathaniel Albert, Ronen Ben-Ami, Thomas J. Walsh, Dimitrios P. Kontoyiannis

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Abstract

Differences in deferasirox susceptibility among members of the order Mucorales are unknown. Here we show that Cunninghamella bertholletiae (four isolates) and Mucor species (five isolates) display higher deferasirox MICs and minimal fungicidal concentrations compared to Rhizopus species (six isolates). Exogenous iron further attenuated the deferasirox susceptibility of Mucorales isolates with low MICs. Vital staining revealed damage to subapical compartments in susceptible strains.

Original language	English (US)
Pages (from-to)	411-413
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	55
Issue number	1
DOIs	https://doi.org/10.1128/AAC.00792-10
State	Published - Jan 2011
Externally published	Yes

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AB - Differences in deferasirox susceptibility among members of the order Mucorales are unknown. Here we show that Cunninghamella bertholletiae (four isolates) and Mucor species (five isolates) display higher deferasirox MICs and minimal fungicidal concentrations compared to Rhizopus species (six isolates). Exogenous iron further attenuated the deferasirox susceptibility of Mucorales isolates with low MICs. Vital staining revealed damage to subapical compartments in susceptible strains.

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Activity of deferasirox in Mucorales: Influences of species and exogenous iron

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