TY - CHAP
T1 - Acute and chronic social defeat
T2 - Stress protocols and behavioral testing
AU - Bartolomucci, Alessandro
AU - Fuchs, Eberhard
AU - Koolhaas, Jaap M.
AU - Ohl, Frauke
PY - 2009
Y1 - 2009
N2 - This chapter provides an overview of experimental approaches for acute and chronic social defeat in male mice and how to test for the behavioral consequences of social stress using the modified hole board. The first part refers to acute social defeat describing the classical resident/intruder test. It summarizes the experimental protocols including behavioral characterizations of the animals. The second part describes various models of chronic defeat and chronic stress such as the sensory contact model, chronic psychosocial stress, social disruption, and repetitive social defeat. The third part is devoted to behavioral testing during/after stress using the modified hole board. Besides an up-to-date collection of protocols, troubleshooting approaches are provided.
AB - This chapter provides an overview of experimental approaches for acute and chronic social defeat in male mice and how to test for the behavioral consequences of social stress using the modified hole board. The first part refers to acute social defeat describing the classical resident/intruder test. It summarizes the experimental protocols including behavioral characterizations of the animals. The second part describes various models of chronic defeat and chronic stress such as the sensory contact model, chronic psychosocial stress, social disruption, and repetitive social defeat. The third part is devoted to behavioral testing during/after stress using the modified hole board. Besides an up-to-date collection of protocols, troubleshooting approaches are provided.
KW - Chronic psychosocial stress
KW - Modified hole board
KW - Repetitive social defeat
KW - Resident/intruder test
KW - Sensory contact model
KW - Social defeat
KW - Social disruption
UR - http://www.scopus.com/inward/record.url?scp=70349789085&partnerID=8YFLogxK
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U2 - 10.1007/978-1-60761-303-9_14
DO - 10.1007/978-1-60761-303-9_14
M3 - Chapter
AN - SCOPUS:70349789085
SN - 9781607613022
T3 - Neuromethods
SP - 261
EP - 275
BT - Mood and Anxiety Related Phenotypes in Mice
PB - Humana Press
ER -