Acute and sub-chronic effects of purified cathinone from khat (Catha edulis) on behavioural profiles in vervet monkeys (Chlorocebus aethiops)

Albert W. Nyongesa, Jemimah A. Oduma, Motohiro Nakajima, Hesbon O. Odongo, Pius A. Adoyo, Mustafa Al'Absi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We investigated the cumulative effects of cathinone on behavioural alterations in single-caged vervet monkeys. Fourteen adult vervets were divided into tests (12 animals) and controls (2 animals), and exposed to escalating doses of cathinone at alternate days of each week for 4 months in presence and absence of cage enrichment. One month of pre-treatment phase served to establish baseline values. Composite behavioural scores of aggression, anxiety, abnormal responses, withdrawal and appetite loss were done. A series of repeated measures analysis of variances were conducted to examine the extent to which cathinone administration was associated with patterns of changes in behavioural data. Results indicate a dose-dependent effect of cathinone on increases of aggression, anxiety, abnormal responses, withdrawal, and appetite loss. The findings demonstrate that at high doses and long-term exposure, cathinone causes behavioural alterations probably via changes in presynaptic striatal dopamine system.

Original languageEnglish (US)
Pages (from-to)441-449
Number of pages9
JournalMetabolic Brain Disease
Volume29
Issue number2
DOIs
StatePublished - Jun 2014

Keywords

  • Behaviour
  • Cathinone
  • Vervet monkeys

Fingerprint Dive into the research topics of 'Acute and sub-chronic effects of purified cathinone from khat (Catha edulis) on behavioural profiles in vervet monkeys (Chlorocebus aethiops)'. Together they form a unique fingerprint.

Cite this