Acute hypotension associated with intraoperative cell salvage using a leukocyte depletion filter during management of obstetric hemorrhage due to amniotic fluid embolism

William Kirke Rogers, Sarah A. Wernimont, Girish C. Kumar, Eliza Bennett, David H. Chestnut

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Amniotic fluid embolism (AFE) is a rare but catastrophic obstetric complication that can lead to profound coagulopathy and hemorrhage. The role of cell salvage and recombinant human Factor VIIa (rFVIIa) administration in such cases remains unclear. We present a case of AFE and describe our experience with the use of cell salvage and rFVIIa administration during the resuscitation. Cell salvage and transfusion through a leukocyte depletion filter was attempted after the diagnosis of AFE was made, but the attempted transfusion was immediately followed by hypotension and a worsening of hemodynamics. rFVIIa, on the contrary, was used with clinical improvement in coagulopathy and without apparent adverse thrombotic effect.

Original languageEnglish (US)
Pages (from-to)449-452
Number of pages4
JournalAnesthesia and analgesia
Volume117
Issue number2
DOIs
StatePublished - Aug 2013
Externally publishedYes

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