Acute leukemia expressing the gamma gene product of the putative second T cell receptor

R. González-Sarmiento, T. W. LeBien, J. G. Bradley, J. M. Greenberg, J. G. Seidman, S. Ang, J. H. Kersey

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Early thymus-derived lymphocytes bearing the Tγ gene product in association with the CD3(T3) complex have recently been described. We report a unique case of human acute lymphoblastic leukemia with a CD2+, CD3+, CD4-, CD5+, CD7+, CD8-, WT31- phenotype. These cells were found to have a Tγ gene rearrangement and Tγ transcripts in absence of Tα or Tβ rearrangements or transcripts. Immunoprecipitation studies with anti-CD3 antibodies showed a 43-kD protein associated with T3; this 43-kD protein is also precipitated with antiserum raised against synthetic peptides representing the constant region of the putative Tγ protein.

Original languageEnglish (US)
Pages (from-to)1281-1284
Number of pages4
JournalJournal of Clinical Investigation
Volume79
Issue number4
DOIs
StatePublished - 1987

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