TY - JOUR
T1 - Acute lithium intoxication and neuroleptic malignant syndrome
AU - Gill, Jasleen
AU - Singh, Harmohan
AU - Nugent, Kenneth
PY - 2003/6/1
Y1 - 2003/6/1
N2 - A 45-year-old man was admitted to our hospital after taking an intentional overdose of 90 sustained-released lithium tablets (450 mg each). The patient was stabilized with three sessions of hemodialysis. On day 7 of his hospital stay, his serum lithium level was 0.5 mEq/L. On day 10, he developed high fever, tachypnea, muscle rigidity, rhabdomyolysis, acute renal insufficiency, mental confusion, and obtundation. His creatine kinase level was 698 IU/L, serum creatinine 3.5 mg/dl. Late-onset neuroleptic malignant syndrome (NMS) was diagnosed. The patient died after developing acute renal failure and acute respiratory distress syndrome. Clinicians should be aware that lithium may cause NMS independent of other neuroleptic agents.
AB - A 45-year-old man was admitted to our hospital after taking an intentional overdose of 90 sustained-released lithium tablets (450 mg each). The patient was stabilized with three sessions of hemodialysis. On day 7 of his hospital stay, his serum lithium level was 0.5 mEq/L. On day 10, he developed high fever, tachypnea, muscle rigidity, rhabdomyolysis, acute renal insufficiency, mental confusion, and obtundation. His creatine kinase level was 698 IU/L, serum creatinine 3.5 mg/dl. Late-onset neuroleptic malignant syndrome (NMS) was diagnosed. The patient died after developing acute renal failure and acute respiratory distress syndrome. Clinicians should be aware that lithium may cause NMS independent of other neuroleptic agents.
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U2 - 10.1592/phco.23.6.811.32179
DO - 10.1592/phco.23.6.811.32179
M3 - Article
C2 - 12820823
AN - SCOPUS:0038350756
SN - 0277-0008
VL - 23
SP - 811
EP - 815
JO - Pharmacotherapy
JF - Pharmacotherapy
IS - 6
ER -