Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group

Katherine Tarlock; Todd A. Alonzo; Pilar P. Moraleda; Robert B. Gerbing; Susana C. Raimondi; Betsy A. Hirsch; Yaddanapudi Ravindranath; Beverly Lange; William G. Woods; Alan S. Gamis; Soheil Meshinchi

doi:10.1111/bjh.12852

Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group

Katherine Tarlock, Todd A. Alonzo, Pilar P. Moraleda, Robert B. Gerbing, Susana C. Raimondi, Betsy A. Hirsch, Yaddanapudi Ravindranath, Beverly Lange, William G. Woods, Alan S. Gamis, Soheil Meshinchi

Laboratory Medicine and Pathology

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Abstract

Summary: Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a rare subtype associated with FLT3-internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of paediatric patients with t(6;9) with and without FLT3-ITD treated on six consecutive cooperative trails were evaluated. In contrast to patients without t(6;9), those with t(6;9) had a significantly lower complete remission rate, higher relapse rate (RR), and poor overall survival (OS). Within t(6;9) patients, those with and without FLT3-ITD had an OS of 40% and 27% respectively (P > 0·9), demonstrating that t(6;9) is a high-risk cytogenetic feature in paediatric AML and its clinical impact is independent of the presence of FLT3-ITD.

Original language	English (US)
Pages (from-to)	254-259
Number of pages	6
Journal	British journal of haematology
Volume	166
Issue number	2
DOIs	https://doi.org/10.1111/bjh.12852
State	Published - Jul 2014

Keywords

Acute myeloid leukaemia
Clinical outcome
FLT3-ITD
Paediatric
T(6; 9)(p23; q34)

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Tarlock, K., Alonzo, T. A., Moraleda, P. P., Gerbing, R. B., Raimondi, S. C., Hirsch, B. A., Ravindranath, Y., Lange, B., Woods, W. G., Gamis, A. S., & Meshinchi, S. (2014). Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group. British journal of haematology, 166(2), 254-259. https://doi.org/10.1111/bjh.12852

Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group. / Tarlock, Katherine; Alonzo, Todd A.; Moraleda, Pilar P. et al.
In: British journal of haematology, Vol. 166, No. 2, 07.2014, p. 254-259.

Research output: Contribution to journal › Article › peer-review

Tarlock, K, Alonzo, TA, Moraleda, PP, Gerbing, RB, Raimondi, SC, Hirsch, BA, Ravindranath, Y, Lange, B, Woods, WG, Gamis, AS & Meshinchi, S 2014, 'Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group', British journal of haematology, vol. 166, no. 2, pp. 254-259. https://doi.org/10.1111/bjh.12852

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abstract = "Summary: Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a rare subtype associated with FLT3-internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of paediatric patients with t(6;9) with and without FLT3-ITD treated on six consecutive cooperative trails were evaluated. In contrast to patients without t(6;9), those with t(6;9) had a significantly lower complete remission rate, higher relapse rate (RR), and poor overall survival (OS). Within t(6;9) patients, those with and without FLT3-ITD had an OS of 40% and 27% respectively (P > 0·9), demonstrating that t(6;9) is a high-risk cytogenetic feature in paediatric AML and its clinical impact is independent of the presence of FLT3-ITD.",

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AU - Moraleda, Pilar P.

AU - Gerbing, Robert B.

AU - Raimondi, Susana C.

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AB - Summary: Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a rare subtype associated with FLT3-internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of paediatric patients with t(6;9) with and without FLT3-ITD treated on six consecutive cooperative trails were evaluated. In contrast to patients without t(6;9), those with t(6;9) had a significantly lower complete remission rate, higher relapse rate (RR), and poor overall survival (OS). Within t(6;9) patients, those with and without FLT3-ITD had an OS of 40% and 27% respectively (P > 0·9), demonstrating that t(6;9) is a high-risk cytogenetic feature in paediatric AML and its clinical impact is independent of the presence of FLT3-ITD.

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Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group

Abstract

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UN SDGs

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