Acute otitis media increases middle ear susceptibility to nasal injection of pseudomonas aeruginosa

Patrick J. Antonelli, Steven S Juhn, G. Scott Giebink, Chap T Le

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6 Scopus citations

Abstract

Pseudomonas aeruginosa was injected intranasally into four groups of chinchillas to determine if these bacteria can invade the middle ear by way of the eustachian tube. One group completed penicillin treatment of bilateral penumococcal otitis media (POM), and the second group started penicillin treatment of bilateral POM at the time of P. aeruginosa injection. A third group had no POM, but completed a course of penicillin treatment before P. aeruginosa injection, and a fourth group had no POM and received no penicillin. Middle ear susceptibility to nasally injected P. aeruginosa was significantly higher in animals with POM (61%) than in animals without POM (32%, p = 0.001). Forced eustachian tube opening pressures did not correlate with P. aeruginosa susceptibility. Thus, P. aeruginosa, the principle pathogen of chronic suppurative otitis media, can invade the middle ear by way of the eustachian tube, and acute otitis media predisposes to middle ear infection by P. aeurginosa.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalOtolaryngology–Head and Neck Surgery
Volume110
Issue number1
DOIs
StatePublished - Jan 1994

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Copyright 2016 Elsevier B.V., All rights reserved.

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