To examine the relationship between acyclovir use and survival in AIDS, we performed a retrospective analysis of data collected through an observational cohort of the 17-site Community Program for Clinical Research on AIDS (CPCRA), under the sponsorship of the National Institute of Allergy and Infectious Diseases. Data were analyzed regarding 2,368 patients with CD4~ lymphocyte counts of <500/mm3, and 7,836 follow-up visits were conducted from September 1990 to July 1994. Factors associated with use of acyclovir were studied by stratified analysis of variance and Mantel-Haenzel χ2 rests. The association between acyclovir and survival was studied with use of the proportional hazards regression model. Individuals reporting acyclovir use were more likely to be white, male, and homosexual; to have a history of herpes simplex and zoster; and to have lower CD4*T cell counts than those who did not. After adjustments for differences in baseline factors, acyclovir use was not associated with prolonged survival.
Bibliographical noteFunding Information:
Received 26 February 1997; revised 14 August 1997. Grant support: National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH), part of the United States Public Health Service. Presented in part at the 3rd Conference on Retroviruses and Opportunistic Infections, held 30 January through 2 February 1996 in Washington, D.C. Reprints or correspondence: Dr. Ramón A. Torres, AIDS Center, St. Vincent’s Hospital and Medical Center, 412 Sixth Avenue, Suite #401, New York, New York 10011.