Acylation of α-aminoalkyl- copper and cuprate reagents with acid chlorides: Improved yields with soluble copper (I) salts

R. Karl Dieter; Ram R. Sharma; Wendy Ryan

doi:10.1016/S0040-4039(96)02411-2

Acylation of α-aminoalkyl- copper and cuprate reagents with acid chlorides: Improved yields with soluble copper (I) salts

R. Karl Dieter, Ram R. Sharma, Wendy Ryan

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Abstract

α-Aminoalkylcopper reagents prepared from soluble CuX·2LiCI give modest to good yields of α-aminoketones upon reaction with acid chlorides, Higher yields are generally obtained with CuCl·2LiCl than with CuCN·2LiCl. Improved yields can be obtained by utilization of cuprate reagents prepared from CuCN·2LiCl and 2.0 equivalents of α-lithiocarbamates.

Original language	English (US)
Pages (from-to)	783-786
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	5
DOIs	https://doi.org/10.1016/S0040-4039(96)02411-2
State	Published - Feb 3 1997
Externally published	Yes

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title = "Acylation of α-aminoalkyl- copper and cuprate reagents with acid chlorides: Improved yields with soluble copper (I) salts",

abstract = "α-Aminoalkylcopper reagents prepared from soluble CuX·2LiCI give modest to good yields of α-aminoketones upon reaction with acid chlorides, Higher yields are generally obtained with CuCl·2LiCl than with CuCN·2LiCl. Improved yields can be obtained by utilization of cuprate reagents prepared from CuCN·2LiCl and 2.0 equivalents of α-lithiocarbamates.",

author = "Dieter, {R. Karl} and Sharma, {Ram R.} and Wendy Ryan",

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journal = "Tetrahedron Letters",

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T1 - Acylation of α-aminoalkyl- copper and cuprate reagents with acid chlorides

T2 - Improved yields with soluble copper (I) salts

AU - Dieter, R. Karl

AU - Sharma, Ram R.

AU - Ryan, Wendy

PY - 1997/2/3

Y1 - 1997/2/3

N2 - α-Aminoalkylcopper reagents prepared from soluble CuX·2LiCI give modest to good yields of α-aminoketones upon reaction with acid chlorides, Higher yields are generally obtained with CuCl·2LiCl than with CuCN·2LiCl. Improved yields can be obtained by utilization of cuprate reagents prepared from CuCN·2LiCl and 2.0 equivalents of α-lithiocarbamates.

AB - α-Aminoalkylcopper reagents prepared from soluble CuX·2LiCI give modest to good yields of α-aminoketones upon reaction with acid chlorides, Higher yields are generally obtained with CuCl·2LiCl than with CuCN·2LiCl. Improved yields can be obtained by utilization of cuprate reagents prepared from CuCN·2LiCl and 2.0 equivalents of α-lithiocarbamates.

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EP - 786

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 5

ER -

Acylation of α-aminoalkyl- copper and cuprate reagents with acid chlorides: Improved yields with soluble copper (I) salts

Abstract

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