Adding MEMS feedback to behavioral smoking cessation therapy increases compliance with bupropion: A replication and extension study

Marc E. Mooney, Shelly L. Sayre, Patricia S. Hokanson, Angela L. Stotts, Joy M. Schmitz

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

This study was conducted to replicate and extend initial positive findings on the usefulness of a Medication Event Monitoring System (MEMS) to assess pill-taking behavior and enhance compliance with bupropion for smoking cessation. Participants (N = 55) received MEMS bottles containing bupropion-SR (150 mg) to be taken twice daily for 7 weeks. For participants randomly assigned to the Enhanced Therapy group (n = 27), weekly individual smoking cessation therapy sessions included an additional 10 min of MEMS feedback and compliance enhancement counseling using CBT techniques. The Usual Care group (n = 28) received weekly individual smoking cessation sessions only. Compliance outcomes included total doses taken and number of doses taken within the prescribed time interval. Results indicated significantly higher compliance over time for the Enhanced Therapy group. Smoking abstinence rates did not differ between the two groups, although results from the pooled sample analysis showed a significant association between level of medication compliance and abstinence status at treatment weeks 3 and 6. Incorporating MEMS-based compliance interventions into smoking pharmacotherapy trials is recommended.

Original languageEnglish (US)
Pages (from-to)875-880
Number of pages6
JournalAddictive Behaviors
Volume32
Issue number4
DOIs
StatePublished - Apr 2007

Bibliographical note

Funding Information:
This research was supported by the NIDA K01-DA-01 9446 (MM), R01 DA-08888 and P50 DA 09262. GlaxoSmithKline provided the bupropion SR. Some data used in the current paper were presented at the Society for Research on Nicotine Tobacco's annual conference in 2003. We thank the participants for taking part in this study.

Keywords

  • Bupropion
  • MEMS
  • Medication compliance

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