Addressing BBB heterogeneity: A new paradigm for drug delivery to brain tumors

Jessica I. Griffith, Sneha Rathi, Wenqiu Zhang, Wenjuan Zhang, Lester R. Drewes, Jann N. Sarkaria, William F. Elmquist

Research output: Contribution to journalReview articlepeer-review

Abstract

Effective treatments for brain tumors remain one of the most urgent and unmet needs in modern oncology. This is due not only to the presence of the neurovascular unit/blood–brain barrier (NVU/BBB) but also to the heterogeneity of barrier alteration in the case of brain tumors, which results in what is referred to as the blood–tumor barrier (BTB). Herein, we discuss this heterogeneity, how it contributes to the failure of novel pharmaceutical treatment strategies, and why a “whole brain” approach to the treatment of brain tumors might be beneficial. We discuss various methods by which these obstacles might be overcome and assess how these strategies are progressing in the clinic. We believe that by approaching brain tumor treatment from this perspective, a new paradigm for drug delivery to brain tumors might be established.

Original languageEnglish (US)
Article number1205
Pages (from-to)1-38
Number of pages38
JournalPharmaceutics
Volume12
Issue number12
DOIs
StatePublished - Dec 2020

Bibliographical note

Funding Information:
The APC was fundsed by National Cancer Institute: CA220378, National Cancer Institute: CA210180, National Institute of Neurological Disorders and Stroke: NS077921, National Institute of Neurological Disorders and Stroke: NS073610.

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Blood-brain barrier
  • Brain metastases
  • BTB
  • NVU/BBB

PubMed: MeSH publication types

  • Journal Article
  • Review

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