Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts

E. C. Oelsner; T. D. Pottinger; K. M. Burkart; M. Allison; S. G. Buxbaum; N. N. Hansel; R. Kumar; E. K. Larkin; L. A. Lange; L. R. Loehr; S. J. London; G. T. O'Connor; G. Papanicolaou; M. F. Petrini; D. Rabinowitz; S. Raghavan; S. Redline; B. Thyagarajan; R. P. Tracy; J. B. Wilk; W. B. White; S. S. Rich; R. G. Barr

doi:10.3109/1354750X.2012.762805

Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts

E. C. Oelsner, T. D. Pottinger, K. M. Burkart, M. Allison, S. G. Buxbaum, N. N. Hansel, R. Kumar, E. K. Larkin, L. A. Lange, L. R. Loehr, S. J. London, G. T. O'Connor, G. Papanicolaou, M. F. Petrini, D. Rabinowitz, S. Raghavan, S. Redline, B. Thyagarajan, R. P. Tracy, J. B. WilkW. B. White, S. S. Rich, R. G. Barr

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Context: Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown. Objective: Test associations of endothelial biomarkers with FEV1 using instrumental variables. Methods: Among 26907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets. Results: ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29mL and-34mL per standard deviation of log-transformed biomarker, p<0.001), as was endothelin-1 among African-Americans (-22mL, p=0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1. The instrumental variable for endothelin-1 was non-informative. Conclusion: Although ICAM-1, P-selectin and endothelin-1 were inversely associated with FEV1, associations for ICAM-1 and P-selectin do not appear causal.

Original language	English (US)
Pages (from-to)	196-203
Number of pages	8
Journal	Biomarkers
Volume	18
Issue number	3
DOIs	https://doi.org/10.3109/1354750X.2012.762805
State	Published - May 1 2013

Keywords

Genetic polymorphisms
Growth factors/cytokines/inflammatory mediators
Respiratory disease

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Oelsner, E. C., Pottinger, T. D., Burkart, K. M., Allison, M., Buxbaum, S. G., Hansel, N. N., Kumar, R., Larkin, E. K., Lange, L. A., Loehr, L. R., London, S. J., O'Connor, G. T., Papanicolaou, G., Petrini, M. F., Rabinowitz, D., Raghavan, S., Redline, S., Thyagarajan, B., Tracy, R. P., ... Barr, R. G. (2013). Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts. Biomarkers, 18(3), 196-203. https://doi.org/10.3109/1354750X.2012.762805

Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts. / Oelsner, E. C.; Pottinger, T. D.; Burkart, K. M.; Allison, M.; Buxbaum, S. G.; Hansel, N. N.; Kumar, R.; Larkin, E. K.; Lange, L. A.; Loehr, L. R.; London, S. J.; O'Connor, G. T.; Papanicolaou, G.; Petrini, M. F.; Rabinowitz, D.; Raghavan, S.; Redline, S.; Thyagarajan, B.; Tracy, R. P.; Wilk, J. B.; White, W. B.; Rich, S. S.; Barr, R. G.

In: Biomarkers, Vol. 18, No. 3, 01.05.2013, p. 196-203.

Research output: Contribution to journal › Article › peer-review

Oelsner, EC, Pottinger, TD, Burkart, KM, Allison, M, Buxbaum, SG, Hansel, NN, Kumar, R, Larkin, EK, Lange, LA, Loehr, LR, London, SJ, O'Connor, GT, Papanicolaou, G, Petrini, MF, Rabinowitz, D, Raghavan, S, Redline, S, Thyagarajan, B, Tracy, RP, Wilk, JB, White, WB, Rich, SS & Barr, RG 2013, 'Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts', Biomarkers, vol. 18, no. 3, pp. 196-203. https://doi.org/10.3109/1354750X.2012.762805

Oelsner, E. C. ; Pottinger, T. D. ; Burkart, K. M. ; Allison, M. ; Buxbaum, S. G. ; Hansel, N. N. ; Kumar, R. ; Larkin, E. K. ; Lange, L. A. ; Loehr, L. R. ; London, S. J. ; O'Connor, G. T. ; Papanicolaou, G. ; Petrini, M. F. ; Rabinowitz, D. ; Raghavan, S. ; Redline, S. ; Thyagarajan, B. ; Tracy, R. P. ; Wilk, J. B. ; White, W. B. ; Rich, S. S. ; Barr, R. G. / Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts. In: Biomarkers. 2013 ; Vol. 18, No. 3. pp. 196-203.

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abstract = "Context: Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown. Objective: Test associations of endothelial biomarkers with FEV1 using instrumental variables. Methods: Among 26907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets. Results: ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29mL and-34mL per standard deviation of log-transformed biomarker, p<0.001), as was endothelin-1 among African-Americans (-22mL, p=0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1. The instrumental variable for endothelin-1 was non-informative. Conclusion: Although ICAM-1, P-selectin and endothelin-1 were inversely associated with FEV1, associations for ICAM-1 and P-selectin do not appear causal.",

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AU - Allison, M.

AU - Buxbaum, S. G.

AU - Hansel, N. N.

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AU - Petrini, M. F.

AU - Rabinowitz, D.

AU - Raghavan, S.

AU - Redline, S.

AU - Thyagarajan, B.

AU - Tracy, R. P.

AU - Wilk, J. B.

AU - White, W. B.

AU - Rich, S. S.

AU - Barr, R. G.

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N2 - Context: Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown. Objective: Test associations of endothelial biomarkers with FEV1 using instrumental variables. Methods: Among 26907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets. Results: ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29mL and-34mL per standard deviation of log-transformed biomarker, p<0.001), as was endothelin-1 among African-Americans (-22mL, p=0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1. The instrumental variable for endothelin-1 was non-informative. Conclusion: Although ICAM-1, P-selectin and endothelin-1 were inversely associated with FEV1, associations for ICAM-1 and P-selectin do not appear causal.

AB - Context: Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown. Objective: Test associations of endothelial biomarkers with FEV1 using instrumental variables. Methods: Among 26907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets. Results: ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29mL and-34mL per standard deviation of log-transformed biomarker, p<0.001), as was endothelin-1 among African-Americans (-22mL, p=0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1. The instrumental variable for endothelin-1 was non-informative. Conclusion: Although ICAM-1, P-selectin and endothelin-1 were inversely associated with FEV1, associations for ICAM-1 and P-selectin do not appear causal.

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