Abstract
Emulsions of ovalbumin in alkylamines, particularly octadecylamine, were compared with an emulsion of ovalbumin in complete Freund’s adjuvant for ability to induce humoral and cell-mediated immune responses in rats. Under defined conditions alkylamine emulsions induced significantly higher IgG immune responses to ovalbumin, but cell-mediated immunity was not significantly different from that induced with complete Freund’s adjuvant. Emulsions of syngeneic myelin basic protein in octadecylamine failed to induce either humoral or cell-mediated immunity to basic protein and neither clinical nor histologic signs of experimental allergic encephalomyelitis ensued. An intranodular injection of octadecylamine into a solid tumor caused significantly enhanced growth of the tumor despite marked necrosis of tumor tissue at the site of injection.
Original language | English (US) |
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Pages (from-to) | 688-695 |
Number of pages | 8 |
Journal | International Archives of Allergy and Immunology |
Volume | 47 |
Issue number | 5 |
DOIs | |
State | Published - Jan 1 1974 |